PMID- 11389214
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20190513
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 533
IP  - Pt 2
DP  - 2001 Jun 1
TI  - Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not 
      skeletal muscle interleukin-6 mRNA, during exercise in humans.
PG  - 585-91
AB  - 1. The present study was undertaken to examine the effects of exercise and 
      carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal 
      muscle and plasma IL-6 concentration. 2. Seven moderately trained men completed 
      60 min of exercise at a workload corresponding to each individual's lactate 
      threshold on four randomised occasions. Two trials were conducted on a bicycle 
      ergometer (Cyc) and two on a running treadmill (Run) either with (CHO) or without 
      (Con) the ingestion of a CHO beverage throughout the exercise. Muscle biopsies 
      were obtained from the vastus lateralis before and immediately after exercise and 
      IL-6 gene expression in these samples was determined using real-time PCR. In 
      addition, venous blood samples were collected at rest, and after 30 min during 
      and at the cessation of exercise. These samples were analysed for plasma IL-6. 3. 
      Irrespective of exercise mode or CHO ingestion, exercise resulted in a 21 +/- 
      4-fold increase (P < 0.01; main exercise effect) in IL-6 mRNA expression. In 
      contrast, while the mode of exercise did not affect the exercise-induced increase 
      in plasma IL-6, CHO ingestion blunted (P < 0.01) this response. 4. These data 
      demonstrate that CHO ingestion attenuates the plasma IL-6 concentration during 
      both cycling and running exercise. However, because IL-6 mRNA expression was 
      unaffected by CHO ingestion, it is likely that the ingestion of CHO during 
      exercise attenuates IL-6 production by tissues other than skeletal muscle.
FAU - Starkie, R L
AU  - Starkie RL
AD  - Exercise Physiology and Metabolism Laboratory, Department of Physiology, The 
      University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Arkinstall, M J
AU  - Arkinstall MJ
FAU - Koukoulas, I
AU  - Koukoulas I
FAU - Hawley, J A
AU  - Hawley JA
FAU - Febbraio, M A
AU  - Febbraio MA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Blood Glucose
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Gene Expression/physiology
MH  - Glycogen/analysis
MH  - Humans
MH  - Interleukin-6/*blood/*genetics
MH  - Male
MH  - Muscle, Skeletal/chemistry/cytology/*physiology
MH  - RNA, Messenger/analysis
PMC - PMC2278645
EDAT- 2001/06/05 10:00
MHDA- 2001/08/03 10:01
PMCR- 2002/06/01
CRDT- 2001/06/05 10:00
PHST- 2001/06/05 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/05 10:00 [entrez]
PHST- 2002/06/01 00:00 [pmc-release]
AID - PHY_11824 [pii]
AID - 10.1111/j.1469-7793.2001.0585a.x [doi]
PST - ppublish
SO  - J Physiol. 2001 Jun 1;533(Pt 2):585-91. doi: 10.1111/j.1469-7793.2001.0585a.x.