PMID- 11389956
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20190901
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 79
IP  - 3-4
DP  - 2001 May 30
TI  - Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and 
      its expression in various tissues.
PG  - 209-18
AB  - Interleukin-18 (IL-18) is a cytokine with potent interferon-gamma-inducing 
      activity, and plays an important biologic role in the enhancement of the activity 
      of natural killer cells and cytotoxic T-lymphocytes. In this study, feline IL-18 
      cDNA was cloned and characterized to establish a basis for the prospective 
      cytokine therapy in small animal practice. The nucleotide sequence of feline 
      IL-18 cDNA obtained in this study was 712bp long and contained its entire open 
      reading frame encoding 192 amino acid residues. The predicted amino acid sequence 
      of feline IL-18 cDNA showed 77.2, 84.8, 60.2 and 62.6% similarity with those of 
      human, dog, rat and mouse counterparts, respectively. The feline IL-18 cDNA 
      included a putative cleavage site of IL-1beta-converting enzyme (ICE) and IL-1 
      signature-like sequences identified in human and mouse IL-18 cDNAs. Expression of 
      IL-18 mRNA was detected in various tissues including spleen, liver and cerebrum 
      in the cat.
FAU - Ishizaka, T
AU  - Ishizaka T
AD  - Department of Veterinary Internal Medicine, Graduate School of Agricultural and 
      Life Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, 
      Japan. aohno@mail.ecc.u-tokyo.ac.jp
FAU - Setoguchi, A
AU  - Setoguchi A
FAU - Masuda, K
AU  - Masuda K
FAU - Ohno, K
AU  - Ohno K
FAU - Tsujimoto, H
AU  - Tsujimoto H
LA  - eng
SI  - GENBANK/AB046211
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cats
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Dogs
MH  - Humans
MH  - Interleukin-18/biosynthesis/*genetics
MH  - Liver/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Spleen/metabolism
MH  - Telencephalon/metabolism
EDAT- 2001/06/08 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - S0165242701002665 [pii]
AID - 10.1016/s0165-2427(01)00266-5 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2001 May 30;79(3-4):209-18. doi: 
      10.1016/s0165-2427(01)00266-5.