PMID- 11390202
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20191025
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 26
IP  - 3
DP  - 2001 Jul
TI  - The correlation of MHC haplotype and development of Behcet's disease-like 
      symptoms induced by herpes simplex virus in several inbred mouse strains.
PG  - 173-81
AB  - It has been postulated that human leukocyte antigen (HLA)-B51 is associated with 
      Behcet's disease. In previous study, we induced Behcet's disease-like symptoms in 
      ICR mice inoculated with herpes simplex virus. In this study, several inbred 
      mouse strains -- B10.BR (H-2k), B10.RIII (H-2r), C57BL/6 (H-2b), C3H/He (H-2k), 
      Balb/c (H-2d) -- which had different types of major histocompatibility complex 
      (MHC), were inoculated with herpes simplex virus type 1 (KOS strain) in order to 
      demonstrate the role of histocompatibility antigen in the development of Behcet's 
      disease-like symptoms. Behcet's disease-like symptoms developed in 40-50% of 
      B10.BR, B10.RIII and C57BL/6 strains, but in only 2% of C3H/He and Balb/c. B10.BR 
      and C3H/He strains had a common haplotype (H-2k) but the rate of manifestation 
      was different. So, we conclude that MHC is not directly correlated with 
      development of Behcet's disease-like symptoms in the animal model of herpes 
      simplex virus induced Behcet's disease-like symptoms.
FAU - Sohn, S
AU  - Sohn S
AD  - Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, 
      Suwon, 442 749, South Korea. sohnsh@madang.ajou.ac.kr
FAU - Lee, E S
AU  - Lee ES
FAU - Lee, S
AU  - Lee S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Behcet Syndrome/pathology/*virology
MH  - Cell Separation
MH  - Cytokines/metabolism
MH  - Flow Cytometry
MH  - *Haplotypes
MH  - Herpes Simplex/*complications
MH  - *Herpesvirus 1, Human
MH  - Major Histocompatibility Complex/*genetics
MH  - Mice
MH  - Mice, Inbred Strains/*genetics/*virology
MH  - Polymerase Chain Reaction
MH  - Spleen/cytology/metabolism
EDAT- 2001/06/08 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - S092318110100086X [pii]
AID - 10.1016/s0923-1811(01)00086-x [doi]
PST - ppublish
SO  - J Dermatol Sci. 2001 Jul;26(3):173-81. doi: 10.1016/s0923-1811(01)00086-x.