PMID- 11390251
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20181130
IS  - 1071-5576 (Print)
IS  - 1071-5576 (Linking)
VI  - 8
IP  - 3
DP  - 2001 May-Jun
TI  - Maternal plasma calcitonin gene-related peptide levels do not change during labor 
      and are not influenced by delivery route.
PG  - 165-8
AB  - OBJECTIVE: Calcitonin gene-related peptide (CGRP) circulates in maternal 
      circulation throughout pregnancy, and specific receptors for CGRP (CGRPrs) are 
      expressed by human myometrium. Because CGRP induces a dose-dependent relaxation 
      of human myometrium, we examined a role for CGRP in modulation of myometrial 
      smooth muscle contractility during pregnancy and labor. The aim of the present 
      study was to evaluate the changes of maternal serum CGRP levels during 
      parturition, according to the mode of delivery and in relation to cervical 
      dilatation. METHODS: Circulating CGRP levels were measured in the following 
      groups of healthy women: nonpregnant women, during the follicular phase of the 
      menstrual cycle (n = 19); at term pregnancy (39-40 weeks; n = 24); after elective 
      cesarean delivery (39-40 weeks; n = 20); and at spontaneous vaginal delivery 
      (39-40 weeks; n = 16). In a subgroup of women, blood samples were collected 
      longitudinally throughout labor at various cervical dilatations in the progress 
      of labor (n = 8). RESULTS: Pregnant women at term not in labor had significantly 
      higher CGRP levels than nonpregnant women (P =.021). No significant difference 
      was found between women who delivered vaginally and those who had elective 
      cesarean, and there were no correlations between CGRP plasma levels and cervical 
      dilatation. CONCLUSIONS: Parturition is characterized by no significant changes 
      in maternal serum CGRP levels, and no significant correlation exists between 
      plasma CGRP levels and cervical dilatation during labor.
FAU - Florio, P
AU  - Florio P
AD  - Department of Obstetrics and Gynecology, University of Siena, Siena, Italy.
FAU - Margutti, A
AU  - Margutti A
FAU - Apa, R
AU  - Apa R
FAU - Miceli, F
AU  - Miceli F
FAU - Pezzani, I
AU  - Pezzani I
FAU - Degli Uberti, E C
AU  - Degli Uberti EC
FAU - Petraglia, F
AU  - Petraglia F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Gynecol Investig
JT  - Journal of the Society for Gynecologic Investigation
JID - 9433806
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Adult
MH  - Calcitonin Gene-Related Peptide/*blood
MH  - Cesarean Section
MH  - Delivery, Obstetric/*methods
MH  - Female
MH  - Follicular Phase
MH  - Gestational Age
MH  - Humans
MH  - Labor Stage, First
MH  - Labor, Obstetric/*physiology
MH  - Pregnancy
EDAT- 2001/06/08 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - S1071557601001034 [pii]
PST - ppublish
SO  - J Soc Gynecol Investig. 2001 May-Jun;8(3):165-8.