PMID- 11391342
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20061115
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 138
IP  - 6
DP  - 2001 Jun
TI  - Primary human herpesvirus 6 infection in liver transplant recipients.
PG  - 921-5
AB  - We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who 
      received living related liver transplantation from their HHV-6 seropositive 
      mothers. Primary HHV-6 infection was confirmed by demonstrating the 
      seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the 
      isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G 
      antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 
      recipients between 2 and 3 weeks after transplantation. Moreover, the virus 
      genome was detected in plasma by polymerase chain reaction in 4 of the 5 
      recipients during the same period. Although the 5 recipients had pyrexia at the 
      time of primary HHV-6 infection, none of the recipients had a skin rash after 
      defervescence. Clinical symptoms disappeared without specific antiviral treatment 
      in all but 1 of the recipients.
FAU - Yoshikawa, T
AU  - Yoshikawa T
AD  - Laboratory of Virology, Research Institute for Disease Mechanism and Control, 
      Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 4668550 
      Japan.
FAU - Ihira, M
AU  - Ihira M
FAU - Suzuki, K
AU  - Suzuki K
FAU - Suga, S
AU  - Suga S
FAU - Asano, Y
AU  - Asano Y
FAU - Asonuma, K
AU  - Asonuma K
FAU - Tanaka, K
AU  - Tanaka K
FAU - Nishiyama, Y
AU  - Nishiyama Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/blood
MH  - Female
MH  - Herpesviridae Infections/*transmission
MH  - *Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - *Liver Transplantation
MH  - Male
MH  - Postoperative Complications
MH  - Tissue Donors
EDAT- 2001/06/08 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - S0022-3476(01)46589-9 [pii]
AID - 10.1067/mpd.2001.113622 [doi]
PST - ppublish
SO  - J Pediatr. 2001 Jun;138(6):921-5. doi: 10.1067/mpd.2001.113622.