PMID- 11391591
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 91
IP  - 11
DP  - 2001 Jun 1
TI  - Familial pulmonary carcinoid tumors.
PG  - 2104-9
AB  - BACKGROUND: Pulmonary carcinoid tumors are rare and usually occur sporadically. 
      Infrequently, they arise in association with multiple endocrine neoplasia type 1 
      (MEN1). Familial pulmonary carcinoid tumors not associated with MEN1 have not 
      been described. METHODS: Two sets of first-degree relatives diagnosed with 
      primary pulmonary carcinoid tumors with no clinical features of MEN1 were 
      identified in a pair of siblings and in a mother and daughter. Mutations in the 
      MEN1 gene were sought using polymerase chain reaction analysis on paraffin 
      embedded tissue from two members of one of the families. RESULTS: Histopathologic 
      and immunohistochemical studies confirmed the diagnoses of carcinoid tumors. None 
      of these patients and no family members had features of MEN1. DNA analysis did 
      not detect germline mutations in the MEN1 gene. CONCLUSIONS: The occurrence of 
      familial pulmonary carcinoid tumors in the absence of MEN1 suggests a novel, rare 
      germline mutation specific to the development of pulmonary carcinoids.
CI  - Copyright 2001 American Cancer Society.
FAU - Oliveira, A M
AU  - Oliveira AM
AD  - Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, 
      Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
FAU - Tazelaar, H D
AU  - Tazelaar HD
FAU - Wentzlaff, K A
AU  - Wentzlaff KA
FAU - Kosugi, N S
AU  - Kosugi NS
FAU - Hai, N
AU  - Hai N
FAU - Benson, A
AU  - Benson A
FAU - Miller, D L
AU  - Miller DL
FAU - Yang, P
AU  - Yang P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (DNA, Neoplasm)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoid Tumor/*genetics
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - *Germ-Line Mutation
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Neoplasm Proteins/analysis
MH  - Pedigree
MH  - Polymerase Chain Reaction
MH  - *Proto-Oncogene Proteins
EDAT- 2001/06/08 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 10.1002/1097-0142(20010601)91:11<2104::AID-CNCR1238>3.0.CO;2-I [pii]
AID - 10.1002/1097-0142(20010601)91:11<2104::aid-cncr1238>3.0.co;2-i [doi]
PST - ppublish
SO  - Cancer. 2001 Jun 1;91(11):2104-9. doi: 
      10.1002/1097-0142(20010601)91:11<2104::aid-cncr1238>3.0.co;2-i.