PMID- 11391720
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20151119
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 67
IP  - 3
DP  - 2001 Jul
TI  - Detection of human herpesvirus 6 and JC virus in progressive multifocal 
      leukoencephalopathy complicating follicular lymphoma.
PG  - 200-5
AB  - Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious 
      disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised 
      patients usually with malignant diseases. We report here a Japanese female with 
      follicular lymphoma who subsequently developed PML. In addition to JCV, human 
      herpesvirus 6 (HHV-6) was detected in the affected brain lesions of the patient 
      by polymerase chain reaction and by in situ hybridization. HHV-6, recognized as a 
      neurotropic virus, is known to be reactivated during immunosuppression and can 
      cause fatal complications such as encephalitis/encephalopathy. It is likely that 
      impaired immunity associated with lymphoma and the additional immunosuppression 
      following cytopenia-inducing chemotherapies predisposed the patient to 
      reactivated HHV-6 infection. Although it remains to be clarified whether HHV-6 
      plays an important role as a co-agent with JCV in causing demyelination of the 
      brain, our observation alerts physicians to the possible association of HHV-6 
      with the pathogenesis of PML.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Daibata, M
AU  - Daibata M
AD  - Department of Medicine, Kochi Medical School, Kochi, Japan. 
      daibatam@kochi-ms.ac.jp
FAU - Hatakeyama, N
AU  - Hatakeyama N
FAU - Kamioka, M
AU  - Kamioka M
FAU - Nemoto, Y
AU  - Nemoto Y
FAU - Hiroi, M
AU  - Hiroi M
FAU - Miyoshi, I
AU  - Miyoshi I
FAU - Taguchi, H
AU  - Taguchi H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (DNA, Viral)
RN  - 0 (Nitrosourea Compounds)
RN  - 0 (Piperazines)
RN  - 11056-06-7 (Bleomycin)
RN  - 5J49Q6B70F (Vincristine)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - BZ114NVM5P (Mitoxantrone)
RN  - R1308VH37P (sobuzoxane)
RN  - RSA8KO39WH (Vindesine)
RN  - RYH2T97J77 (ranimustine)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
MH  - Bleomycin/administration & dosage/adverse effects
MH  - Brain/pathology/virology
MH  - Cyclophosphamide/administration & dosage/adverse effects
MH  - DNA, Viral/isolation & purification
MH  - Doxorubicin/administration & dosage/adverse effects
MH  - Etoposide/administration & dosage/adverse effects
MH  - Fatal Outcome
MH  - Female
MH  - Herpesviridae Infections/complications/*virology
MH  - Herpesvirus 6, Human/*isolation & purification/pathogenicity/physiology
MH  - Humans
MH  - Immunity, Cellular/drug effects
MH  - Immunocompromised Host
MH  - JC Virus/*isolation & purification/pathogenicity/physiology
MH  - Leukoencephalopathy, Progressive Multifocal/etiology/pathology/*virology
MH  - Lymphoma, Follicular/*complications/drug therapy
MH  - Magnetic Resonance Imaging
MH  - Mitoxantrone/administration & dosage/adverse effects
MH  - Nitrosourea Compounds/administration & dosage/adverse effects
MH  - Papillomavirus Infections/complications/*virology
MH  - Piperazines/administration & dosage/adverse effects
MH  - Polymerase Chain Reaction
MH  - Prednisolone/administration & dosage/adverse effects
MH  - Recurrence
MH  - Salvage Therapy
MH  - Vincristine/administration & dosage/adverse effects
MH  - Vindesine/administration & dosage/adverse effects
MH  - Virus Activation
EDAT- 2001/06/08 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 10.1002/ajh.1108 [doi]
PST - ppublish
SO  - Am J Hematol. 2001 Jul;67(3):200-5. doi: 10.1002/ajh.1108.