PMID- 11392345
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20141120
IS  - 0890-8567 (Print)
IS  - 0890-8567 (Linking)
VI  - 40
IP  - 6
DP  - 2001 Jun
TI  - Adult psychosocial outcome of prepubertal major depressive disorder.
PG  - 673-7
AB  - OBJECTIVE: To compare adult psychosocial functioning (PSF) of subjects with 
      prepubertal major depressive disorder (PMDD) to a normal comparison (NC) group. 
      METHOD: PSF of subjects with PMDD (n = 72) and of NC subjects (n = 28) was 
      compared after prospective follow-up to adulthood. These 100 subjects were 90.9% 
      of the baseline 110 subjects who participated in the "Nortriptyline in Childhood 
      Depression: Follow-up Study." Research nurses who were blind to group status 
      conducted telephone interviews using the Longitudinal Interval Follow-up 
      Evaluation (LIFE) to obtain PSF data. RESULTS: At follow-up, the PMDD group was 
      20.7+/-2.0 and the NC subjects were 20.9+/-2.2 years old. The PMDD subjects were 
      10.3+/-1.5 years old at baseline. Time between baseline and follow-up was 
      9.9+/-1.5 years. In the PMDD group, subjects with MDD, bipolar disorder, or 
      substance use disorders during the previous 5 years had significantly worse PSF 
      than NC subjects. These PSF impairments included significantly worse 
      relationships with parents, siblings, and friends; significantly worse 
      functioning in household, school, and work settings; and worse overall quality of 
      life and global social adjustment. CONCLUSIONS: Although combined treatments for 
      PMDD have little scientific basis, multimodality regimens seem prudent until 
      definitive treatment data become available.
FAU - Geller, B
AU  - Geller B
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 
      63110, USA. gellerb@medicine.wustl.edu
FAU - Zimerman, B
AU  - Zimerman B
FAU - Williams, M
AU  - Williams M
FAU - Bolhofner, K
AU  - Bolhofner K
FAU - Craney, J L
AU  - Craney JL
LA  - eng
GR  - R01 MH-40273/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - BL03SY4LXB (Nortriptyline)
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Antidepressive Agents, Tricyclic/therapeutic use
MH  - Child
MH  - Depressive Disorder, Major/diagnosis/drug therapy/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Nortriptyline/therapeutic use
MH  - Psychiatric Status Rating Scales
MH  - Psychology, Child
MH  - *Social Adjustment
EDAT- 2001/06/08 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - S0890-8567(09)60471-8 [pii]
AID - 10.1097/00004583-200106000-00012 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2001 Jun;40(6):673-7. doi: 
      10.1097/00004583-200106000-00012.