PMID- 11393726
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20190901
IS  - 1387-2273 (Print)
IS  - 1387-2273 (Linking)
VI  - 755
IP  - 1-2
DP  - 2001 May 5
TI  - Multi-residue analysis of avermectins in swine liver by immunoaffinity extraction 
      and liquid chromatography-mass spectrometry.
PG  - 361-6
AB  - A multi-residue LC-MS method was developed to determine avermectin residues in 
      swine liver. Abamectin and ivermectin (22,23-dihydroabamectin) were extracted, 
      and cleaned up by immunoaffinty columns with immobilized anti-avermectin 
      polyclonal antibodies. The cleaned samples were separated by high-performance 
      liquid chromatography (HPLC) with a C8 column and determined by negative-ion 
      atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) using 
      selective ion monitoring (SIM) of [M-H]-. Recoveries of abamectin and ivermectin 
      from fortified samples at 5-100 microg kg(-1) levels ranged from 74 to 94% and 
      from 65 to 87%, respectively. The limits of detection were 5 microg of abamectin 
      or ivermectin in 1 kg sample.
FAU - Wu, Z
AU  - Wu Z
AD  - College of Chemistry and Molecular Engineering, Peking University, Beijing, 
      China.
FAU - Li, J
AU  - Li J
FAU - Zhu, L
AU  - Zhu L
FAU - Luo, H
AU  - Luo H
FAU - Xu, X
AU  - Xu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Chromatogr B Biomed Sci Appl
JT  - Journal of chromatography. B, Biomedical sciences and applications
JID - 9714109
RN  - 0 (Anthelmintics)
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Immunosorbents)
RN  - 70288-86-7 (Ivermectin)
RN  - 73989-17-0 (avermectin)
SB  - IM
MH  - Animals
MH  - Anthelmintics/*analysis/chemistry
MH  - Antiprotozoal Agents/*analysis/chemistry
MH  - Chromatography, Affinity
MH  - Chromatography, Liquid/methods
MH  - Immunosorbents
MH  - Ivermectin/analogs & derivatives/*analysis/chemistry
MH  - Liver/*chemistry/metabolism
MH  - Mass Spectrometry
MH  - Molecular Structure
MH  - Sensitivity and Specificity
MH  - Swine
EDAT- 2001/06/08 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 10.1016/s0378-4347(01)00077-9 [doi]
PST - ppublish
SO  - J Chromatogr B Biomed Sci Appl. 2001 May 5;755(1-2):361-6. doi: 
      10.1016/s0378-4347(01)00077-9.