PMID- 11394193
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20181113
IS  - 1180-4882 (Print)
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Linking)
VI  - 26
IP  - 3
DP  - 2001 May
TI  - Novelty-elicited mismatch negativity in patients with schizophrenia on admission 
      and discharge.
PG  - 235-46
AB  - OBJECTIVE: Given recent reports of differences between mismatch negativity (MMN) 
      elicited by always novel sounds (novelty-elicited MMN) and that elicited by 
      repeated rare deviants (conventional MMN), we investigated novelty-elicited MMN 
      and P3a in patients with schizophrenia before and after a nonstandardized 
      inpatient treatment. DESIGN: Electrophysiological and clinical assessment of 
      patients on admission and discharge from hospital. Assessment of control subjects 
      on 2 sessions. SETTING: Inpatient treatment in a psychiatric university hospital. 
      SUBJECTS: 20 patients with schizophrenia and 21 healthy control subjects of 
      similar age and sex. Selection of patients with first- to third-episode 
      schizophrenia. OUTCOME MEASURES: Early and late component MMN amplitudes and 
      latencies, P3a amplitudes and latencies, Positive and Negative Syndrome Scale 
      (PANSS), Global Assessment of Functioning (GAF), Extrapyramidal Symptom Scale 
      (EPS), Abnormal Involuntary Movement Scale (AIMS) and chlorpromazine equivalents. 
      RESULTS: In patients with schizophrenia, novelty-elicited MMN was unimpaired on 
      admission, and there was a statistically significant reduction of the late MMN 
      component with treatment. Improvements in symptom expression were associated with 
      increased latencies of the early MMN component. CONCLUSION: Results indicate 
      differences in information processing between conventional and novelty-elicited 
      MMN. Some components of the novelty-elicited MMN might be more state dependent 
      than those of the conventional MMN.
FAU - Grzella, I
AU  - Grzella I
AD  - Clinic for Child and Adolescent Psychiatry and Psychotherapy, Technical 
      University Aachen, Aachen, Germany.
FAU - Muller, B W
AU  - Muller BW
FAU - Oades, R D
AU  - Oades RD
FAU - Bender, S
AU  - Bender S
FAU - Schall, U
AU  - Schall U
FAU - Zerbin, D
AU  - Zerbin D
FAU - Wolstein, J
AU  - Wolstein J
FAU - Sartory, G
AU  - Sartory G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Arousal/drug effects/*physiology
MH  - Attention/drug effects/*physiology
MH  - Cerebral Cortex/drug effects/physiopathology
MH  - Contingent Negative Variation/drug effects/*physiology
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Patient Admission
MH  - Patient Discharge
MH  - Psychiatric Status Rating Scales
MH  - Reaction Time/drug effects/physiology
MH  - Schizophrenia/drug therapy/*physiopathology
PMC - PMC1408303
EDAT- 2001/06/08 10:00
MHDA- 2001/07/06 10:01
PMCR- 2001/05/01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
PHST- 2001/05/01 00:00 [pmc-release]
PST - ppublish
SO  - J Psychiatry Neurosci. 2001 May;26(3):235-46.