PMID- 11394297
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20190822
IS  - 0003-2654 (Print)
IS  - 0003-2654 (Linking)
VI  - 126
IP  - 5
DP  - 2001 May
TI  - Sensitive determination of methylenedioxylated amphetamines by liquid 
      chromatography.
PG  - 581-6
AB  - Different strategies for the liquid chromatographic determination of 
      methylenedioxylated amphetamines were evaluated: separation and detection of 
      underivatized analytes by (i) UV or (ii) fluorescence, (iii) derivatization with 
      3,5-dinitrobenzoyl chloride followed by separation and UV detection of the 
      derivatives formed and (iv) derivatization with 9-fluorenylmethyl chloroformate 
      (FMOC) and subsequent separation and fluorimetric detection of the derivatives. 
      The compounds tested were 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethylamphetamine 
      (MDE). On the basis of these studies, a new procedure for the chromatographic 
      determination of MDA, MDMA and MDE is proposed, based on derivatization with 
      FMOC. The described procedure allows the quantification of the tested compounds 
      with adequate linearity, reproducibility and accuracy in the concentration 
      interval 0.5-20.0 micrograms mL-1. The limits of detection were 0.01 microgram 
      mL-1 for MDA and 0.025 microgram mL-1 for MDMA and MDE. The utility of the 
      described assay was tested by determining methylenedioxylated amphetamines in 
      plasma and urine.
FAU - Herraez-Hernandez, R
AU  - Herraez-Hernandez R
AD  - Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100 
      Burjassot, Valencia, Spain.
FAU - Campins-Falco, P
AU  - Campins-Falco P
FAU - Verdu-Andres, J
AU  - Verdu-Andres J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Amphetamines)
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/analysis/blood/urine
MH  - Amphetamines/*analysis/blood/urine
MH  - Chromatography, Liquid/methods
MH  - Hallucinogens/*analysis/blood/urine
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis/blood/urine
EDAT- 2001/06/08 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 10.1039/b010035h [doi]
PST - ppublish
SO  - Analyst. 2001 May;126(5):581-6. doi: 10.1039/b010035h.