PMID- 11395552
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190822
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 25
IP  - 6
DP  - 2001 Jun
TI  - Cystic endocrine tumors of the pancreas: clinical, radiologic, and 
      histopathologic features in 13 cases.
PG  - 752-60
AB  - Cystic endocrine tumors of the pancreas are rare and raise difficult clinical 
      problems. Our aims were to reevaluate the diagnostic and therapeutic strategy and 
      to assess their histopathologic characteristics. Thirteen cystic endocrine tumors 
      diagnosed in 10 patients were included. Clinical, radiologic, and pathologic data 
      were reviewed. There were 6 male and 4 female patients (median age, 46 yrs). Six 
      patients had evidence of multiple endocrine neoplasia type 1 (MEN1) disease. Four 
      had a functional endocrine syndrome. Ten tumors were visible on imaging studies. 
      The most suggestive radiologic features were the existence of a peripheral 
      hypervascular rim (10 cases) and images of cyst into cyst (two cases). On gross 
      and histologic examinations, two distinct types were present. Macrocystic tumors 
      (six cases) were unilocular and limited by a thick wall containing nests of tumor 
      cells. Microcystic tumors (seven cases) were characterized by the presence of 
      multiple cystic spaces directly lined by tumor cells. Surgical resection was 
      performed in all cases. Three patients had lymph node metastases at the time of 
      diagnosis. One patient is dead with metastatic dissemination. The others are 
      alive without recurrence or metastasis. The diagnosis of endocrine tumor must be 
      considered for any pancreatic cyst discovered in a patient with a history of MEN1 
      syndrome or with clinical features suggestive of this syndrome. Cystic pancreatic 
      endocrine tumors must be treated by surgical resection because of their possible 
      malignant evolution.
FAU - Ligneau, B
AU  - Ligneau B
AD  - Federation des Specialites Digestives, Hopital Edouard Herriot, Lyon, France.
FAU - Lombard-Bohas, C
AU  - Lombard-Bohas C
FAU - Partensky, C
AU  - Partensky C
FAU - Valette, P J
AU  - Valette PJ
FAU - Calender, A
AU  - Calender A
FAU - Dumortier, J
AU  - Dumortier J
FAU - Gouysse, G
AU  - Gouysse G
FAU - Boulez, J
AU  - Boulez J
FAU - Napoleon, B
AU  - Napoleon B
FAU - Berger, F
AU  - Berger F
FAU - Chayvialle, J A
AU  - Chayvialle JA
FAU - Scoazec, J Y
AU  - Scoazec JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
SB  - IM
MH  - Adult
MH  - Cysts/*diagnostic imaging/*pathology
MH  - Endocrine Gland Neoplasms/*diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*diagnostic imaging/*pathology
MH  - Radiography
EDAT- 2001/06/08 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 10.1097/00000478-200106000-00006 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2001 Jun;25(6):752-60. doi: 10.1097/00000478-200106000-00006.