PMID- 11395757
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20091119
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 411
IP  - 6838
DP  - 2001 Jun 7
TI  - Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
PG  - 654-6
AB  - Alzheimer's disease is characterized by accumulation in the brain of a family of 
      insoluble amyloid peptides (Abeta peptides), which are produced as a result of 
      the normal processing of beta-amyloid precursor protein (beta-APP). Russo et al. 
      claim that a truncated Abeta peptide that lacks the first ten amino acids 
      accumulates in the brains of patients carrying a mutant form of pre-senilin 1 
      (PS1), a protein that is involved in cleavage of beta-APP. However, we have found 
      that this same species is also overrepresented in Alzheimer's patients with 
      mutations in beta-APP itself. Our findings do not support the conclusion of Russo 
      et al. that pathogenic PS1 mutations may control cleavage of beta-APP by 
      beta-secretase.
FAU - Gandy, S
AU  - Gandy S
AD  - Sir James McCusker Alzheimer Research Unit, University of Western Australia, 
      Perth, Australia and Department of Psychiatry, New York University School of 
      Medicine, New York 10962, USA. samgandy@earthlink.net
FAU - Naslund, J
AU  - Naslund J
FAU - Nordstedt, C
AU  - Nordstedt C
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Amyloid)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Membrane Proteins)
RN  - 0 (PSEN1 protein, human)
RN  - 0 (Presenilin-1)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.46 (BACE1 protein, human)
SB  - IM
CON - Nature. 2000 Jun 1;405(6786):531-2. PMID: 10850703
MH  - Aged
MH  - Alzheimer Disease/*genetics
MH  - Amyloid/metabolism
MH  - Amyloid Precursor Protein Secretases
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Aspartic Acid Endopeptidases
MH  - Brain/metabolism
MH  - Endopeptidases/metabolism
MH  - Humans
MH  - Membrane Proteins/*genetics/metabolism
MH  - *Mutation
MH  - Presenilin-1
EDAT- 2001/06/08 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/06/08 10:00
PHST- 2001/06/08 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/06/08 10:00 [entrez]
AID - 35079682 [pii]
AID - 10.1038/35079682 [doi]
PST - ppublish
SO  - Nature. 2001 Jun 7;411(6838):654-6. doi: 10.1038/35079682.