PMID- 11396750
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20220330
IS  - 0946-1965 (Print)
IS  - 0946-1965 (Linking)
VI  - 39
IP  - 3
DP  - 2001 Mar
TI  - A randomized trial to compare the efficacy, safety, cost and platelet aggregation 
      effects of enoxaparin and unfractionated heparin (the ESCAPEU trial).
PG  - 110-5
AB  - OBJECTIVE: To compare the efficacy, safety, cost and effects on platelet 
      aggregation of unfractionated heparin and low-molecular weight heparin in 
      unstable angina patients. PATIENTS AND METHODS: Ninety-three patients with 
      unstable angina were randomized to receive either unfractionated heparin (UFH) or 
      enoxaparin in an open design clinical trial with blinded end point evaluation. 
      The effects of the heparins on platelet aggregation were also compared. RESULTS: 
      The composite end point of myocardial infarction, cardiac death, recurrent angina 
      and need for intervention was observed in 62% of patients treated with UFH and in 
      37% of patients treated with enoxaparin (RR 1.7, 95% CI 0.75 to 3.71, p = 0.04). 
      There was no difference in the frequency or severity of adverse events. A 
      cost-effectiveness analysis showed both the heparins to be similar. Platelet 
      aggregation was inhibited to a greater extent by UFH when compared to enoxaparin. 
      CONCLUSIONS: Enoxaparin appears to be superior in efficacy to UFH and similar to 
      UFH in safety. No difference in costs was detected in this study. The greater 
      inhibition of platelet aggregation observed in the case of UFH compared to 
      enoxaparin indicates that there may be more bleeding complications with UFH.
FAU - Malhotra, S
AU  - Malhotra S
AD  - Department of Pharmacology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Bhargava, V K
AU  - Bhargava VK
FAU - Grover, A
AU  - Grover A
FAU - Pandhi, P
AU  - Pandhi P
FAU - Sharma, Y P
AU  - Sharma YP
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Int J Clin Pharmacol Ther
JT  - International journal of clinical pharmacology and therapeutics
JID - 9423309
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina Pectoris/*drug therapy
MH  - Anticoagulants/adverse effects/economics/*pharmacology
MH  - Cost-Benefit Analysis
MH  - Enoxaparin/adverse effects/economics/*pharmacology
MH  - Female
MH  - Heparin/adverse effects/economics/*pharmacology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation/*drug effects
EDAT- 2001/06/09 10:00
MHDA- 2001/10/12 10:01
CRDT- 2001/06/09 10:00
PHST- 2001/06/09 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/06/09 10:00 [entrez]
AID - 10.5414/cpp39110 [doi]
PST - ppublish
SO  - Int J Clin Pharmacol Ther. 2001 Mar;39(3):110-5. doi: 10.5414/cpp39110.