PMID- 11398839
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190513
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 60
IP  - 6
DP  - 2001 Jun
TI  - Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: 
      diagnostic and prognostic implications.
PG  - 628-36
AB  - The second most frequently reported genetic abnormalities in meningiomas after 
      22q loss are deletions of 1p and 14q. To assess the potential diagnostic and 
      prognostic utility of these chromosomal alterations, we studied 180 
      well-characterized meningiomas using dual-color fluorescence in situ 
      hybridization (FISH) with DNA probes localized to 1p32, 1p36, 14q13, and 14q32. 
      Our cohort consisted of 77 benign (grade I), 74 atypical (grade II), and 29 
      anaplastic (grade III) meningiomas. Benign and atypical meningiomas were further 
      stratified into subsets of recurring (despite gross total resection) vs 
      non-recurring (at least 10 yr of follow-up) and mitotically active vs brain 
      invasive subsets, respectively. Losses of 1p and 14q losses were identified in 
      23% and 31% of benign, 56% and 57% of atypical, and 75% and 67% of anaplastic 
      meningiomas, respectively (p < 0.001 for 1p; p = 0.004 for 14q). Combined 1p/14q 
      deletions were encountered in 7% benign. 39% atypical, and 63% anaplastic 
      meningiomas (p < 0.001). Benign non-recurring meningiomas were less likely to 
      harbor 14q deletions than recurring examples (17% vs 50%, p = 0.013). There was a 
      trend for anaplastic meningiomas with 14q deletions and atypical meningiomas with 
      combined 1p/14q deletions to have poorer overall survivals, though neither 
      reached statistical significance. We conclude that 1p and 14q deletions are 
      highly associated with increasing histologic grade and play an important role in 
      meningioma tumor progression. Furthermore, 14q FISH analysis may aid in assessing 
      recurrence risk in histologically benign meningiomas.
FAU - Cai, D X
AU  - Cai DX
AD  - Department of Pathology, MetroHealth Medical Center, Case Western Reserve 
      University School of Medicine, Cleveland, Ohio, USA.
FAU - Banerjee, R
AU  - Banerjee R
FAU - Scheithauer, B W
AU  - Scheithauer BW
FAU - Lohse, C M
AU  - Lohse CM
FAU - Kleinschmidt-Demasters, B K
AU  - Kleinschmidt-Demasters BK
FAU - Perry, A
AU  - Perry A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 14
MH  - Cohort Studies
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningeal Neoplasms/*genetics
MH  - Meningioma/*genetics
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
EDAT- 2001/06/12 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/06/12 10:00
PHST- 2001/06/12 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/06/12 10:00 [entrez]
AID - 10.1093/jnen/60.6.628 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2001 Jun;60(6):628-36. doi: 10.1093/jnen/60.6.628.