PMID- 11400112
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 95
IP  - 4
DP  - 2001 Jul 20
TI  - Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and 
      prognosis in laryngeal squamous cell carcinomas.
PG  - 209-15
AB  - Cyclin D1 and its catalytic partner CDK4 are known to play important roles in the 
      G1/S checkpoint of the cell cycle. The complex formed by CDK4 and cyclin D1 has 
      been strongly implicated in the control of cell proliferation and prognoses in 
      human malignancies. We investigated the immunohistochemical expression of cyclin 
      D1, CDK4 and proliferating cell nuclear antigen (PCNA) in 102 patients with 
      laryngeal squamous cell carcinoma (LSCC). Cyclin D1 overexpression was observed 
      in 59 cases (57.8%) of LSCC, and was significantly correlated with tumor site, 
      tumor size, lymph node metastasis and advanced stage. CDK4 overexpression was 
      observed in 48 cases (47.1%), and was significantly correlated with tumor size 
      and advanced stage. Cyclin D1 and CDK4 expression was significantly associated 
      with cell proliferation measured by PCNA (r = 0.812, p < 0.0001 and r = 0.725, p 
      < 0.0001, respectively). The Kaplan-Meier analysis showed that cyclin D1 
      overexpression was significantly associated with disease-free survival and 
      overall survival. CDK4 overexpression was significantly associated with overall 
      survival. When cyclin D1 and CDK4 are combined, the patients with 
      co-overexpression of cyclin D1-CDK4 revealed the poorest overall survival. 
      Additionally, in early-stage (I-II) cases, co-overexpression of cyclin D1-CDK4 
      was also revealed to possess a significant prognostic role. By multivariate 
      analysis, cyclin D1 overexpression, lymph node metastasis and advanced stage were 
      independent prognostic factors for disease-free survival. Cyclin D1 
      overexpression, CDK4 overexpression, tumor grade, lymph node metastasis and 
      advanced stage were independent prognostic factors for overall survival. These 
      findings indicate that cyclin D1 and CDK4 overexpression and/or co-overexpression 
      of these proteins may play a pivotal role in the biological behavior of LSCC and 
      may provide a strong prognostic implication.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Dong, Y
AU  - Dong Y
AD  - Department of Physiology, Kagawa Medical University, Kagawa, Japan.
FAU - Sui, L
AU  - Sui L
FAU - Sugimoto, K
AU  - Sugimoto K
FAU - Tai, Y
AU  - Tai Y
FAU - Tokuda, M
AU  - Tokuda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 136601-57-5 (Cyclin D1)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*diagnosis/mortality/pathology
MH  - China/epidemiology
MH  - Cyclin D1/*metabolism
MH  - Cyclin-Dependent Kinase 4
MH  - Cyclin-Dependent Kinases/*metabolism
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*diagnosis/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - *Proto-Oncogene Proteins
MH  - Regression Analysis
MH  - Survival Rate
EDAT- 2001/06/16 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/16 10:00
PHST- 2001/06/16 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/16 10:00 [entrez]
AID - 10.1002/1097-0215(20010720)95:4<209::AID-IJC1036>3.0.CO;2-R [pii]
AID - 10.1002/1097-0215(20010720)95:4<209::aid-ijc1036>3.0.co;2-r [doi]
PST - ppublish
SO  - Int J Cancer. 2001 Jul 20;95(4):209-15. doi: 
      10.1002/1097-0215(20010720)95:4<209::aid-ijc1036>3.0.co;2-r.