PMID- 11401094
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190921
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 80
IP  - 4
DP  - 2001 Apr
TI  - Acute promyelocytic leukemia with additional chromosome abnormalities in a renal 
      transplant case.
PG  - 246-50
AB  - Some cases of acute myeloid leukemia following organ transplant (PT-AML) have 
      been published in the literature. We report the second case of acute 
      promyelocytic leukemia (APL), which developed post-transplant and 
      immunosuppressive treatment, in a 50-year-old male who had undergone a renal 
      transplant. At diagnosis he presented typical t(15;17)(q12;q13) with additional 
      abnormalities, including +8,t(13;22)(q12;q13) and an abnormal chromosome 1 which 
      was better characterized by fluorescence in situ hybridization (FISH). He 
      obtained cytological, karyotypic and molecular complete remission (CR) with 
      induction treatment according to the all-trans retinoic acid + idarubican (AIDA) 
      protocol; after 12 months, he relapsed (molecular relapse) and achieved molecular 
      remission with all-trans retinoic acid (ATRA) plus mitoxantrone and cytosine 
      arabinoside. After a further 14 months, he was treated with arsenic trioxide for 
      cytological relapse and obtained a third CR; at the cytological relapse the 
      karyotype showed 47,XY,+8, 
      t(15;17)(q22;q21),t(13;22)(q12;q13),der(22)t(1;22)(p22;q13). He is alive 3.3 
      years after diagnosis of APL. Cyclosporin A (CsA) was given during all cycles of 
      chemotherapy. We did not observe any severe infections or kidney failure during 
      treatments. The use of conventional cytogenetic analysis plus FISH may identify 
      complex karyotype also in transplanted patients receiving immunotherapy, and may 
      also contribute to a better assessment of PT-AL.
FAU - Specchia, G
AU  - Specchia G
AD  - Department of Hematology, University of Bari, Italy. emadhba@cimedoc.uniba.it
FAU - Storlazzi, C T
AU  - Storlazzi CT
FAU - Cuneo, A
AU  - Cuneo A
FAU - Surace, C
AU  - Surace C
FAU - Mestice, A
AU  - Mestice A
FAU - Pannunzio, A
AU  - Pannunzio A
FAU - Rocchi, M
AU  - Rocchi M
FAU - Liso, V
AU  - Liso V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Immunosuppressive Agents)
RN  - 04079A1RDZ (Cytarabine)
RN  - 5688UTC01R (Tretinoin)
RN  - BZ114NVM5P (Mitoxantrone)
RN  - ZRP63D75JW (Idarubicin)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 15
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 22
MH  - Cytarabine/therapeutic use
MH  - Humans
MH  - Idarubicin/therapeutic use
MH  - Immunosuppressive Agents/*adverse effects
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Transplantation/*adverse effects
MH  - Leukemia, Promyelocytic, Acute/*etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mitoxantrone/therapeutic use
MH  - Polycystic Kidney Diseases/surgery
MH  - Recurrence
MH  - Remission Induction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tretinoin/therapeutic use
EDAT- 2001/06/13 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/06/13 10:00
PHST- 2001/06/13 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/06/13 10:00 [entrez]
AID - 10.1007/s002770000273 [doi]
PST - ppublish
SO  - Ann Hematol. 2001 Apr;80(4):246-50. doi: 10.1007/s002770000273.