PMID- 11402254
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20191104
IS  - 1526-484X (Print)
IS  - 1526-484X (Linking)
VI  - 11
IP  - 2
DP  - 2001 Jun
TI  - High-fat diet versus habitual diet prior to carbohydrate loading: effects of 
      exercise metabolism and cycling performance.
PG  - 209-25
AB  - We examined the effects of a high-fat diet (HFD-CHO) versus a habitual diet, 
      prior to carbohydrate (CHO)-loading on fuel metabolism and cycling time-trial 
      (TT) performance. Five endurance-trained cyclists participated in two 14-day 
      randomized cross-over trials during which subjects consumed either a HFD (> 65% 
      MJ from fat) or their habitual diet (CTL) (30 +/- 5% MJ from fat) for 10 day, 
      before ingesting a high-CHO diet (CHO-loading, CHO > 70% MJ) for 3 days. Trials 
      consisted of a 150-min cycle at 70% of peak oxygen uptake (VaO2peak), followed 
      immediately by a 20-km TT. One hour before each trial, cyclists ingested 400 ml 
      of a 3.44% medium-chain triacylglycerol (MCT) solution, and during the trial, 
      ingested 600 ml/hour of a 10% 14C-glucose + 3.44% MCT solution. The dietary 
      treatments did not alter the subjects' weight, body fat, or lipid profile. There 
      were also no changes in circulating glucose, lactate, free fatty acid (FFA), and 
      b-hydroxybutyrate concentrations during exercise. However, mean serum glycerol 
      concentrations were significantly higher (p < .01) in the HFD-CHO trial. The 
      HFD-CHO diet increased total fat oxidation and reduced total CHO oxidation but 
      did not alter plasma glucose oxidation during exercise. By contrast, the 
      estimated rates of muscle glycogen and lactate oxidation were lower after the 
      HFD-CHO diet. The HFD-CHO treatment was also associated with improved TT times 
      (29.5 +/- 2.9 min vs. 30.9 +/- 3.4 min for HFD-CHO and CTL-CHO, p <.05). High-fat 
      feeding for 10 days prior to CHO-loading was associated with an increased 
      reliance on fat, a decreased reliance on muscle glycogen, and improved time trial 
      performance after prolonged exercise.
FAU - Lambert, E V
AU  - Lambert EV
AD  - Research Unit for Exercise Science and Sports Medicine in the Department of Human 
      Biology, Faculty of Health Sciences, University of Cape Town, Sports Science 
      Institute of South Africa, Newlands 7725, Cape Town, South Africa.
FAU - Goedecke, J H
AU  - Goedecke JH
FAU - Zyle, C
AU  - Zyle C
FAU - Murphy, K
AU  - Murphy K
FAU - Hawley, J A
AU  - Hawley JA
FAU - Dennis, S C
AU  - Dennis SC
FAU - Noakes, T D
AU  - Noakes TD
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 9005-79-2 (Glycogen)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Bicycling/*physiology
MH  - Blood Glucose/metabolism
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*administration & dosage/metabolism
MH  - Dietary Fats/*administration & dosage/metabolism
MH  - *Energy Metabolism
MH  - Feeding Behavior
MH  - Glycerol/blood
MH  - Glycogen/metabolism
MH  - Humans
MH  - Male
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
EDAT- 2001/06/13 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/13 10:00
PHST- 2001/06/13 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/13 10:00 [entrez]
AID - 10.1123/ijsnem.11.2.209 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2001 Jun;11(2):209-25. doi: 
      10.1123/ijsnem.11.2.209.