PMID- 11403666
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20190901
IS  - 0160-564X (Print)
IS  - 0160-564X (Linking)
VI  - 25
IP  - 5
DP  - 2001 May
TI  - Change in vasoconstrictive function during prolonged nonpulsatile left heart 
      bypass.
PG  - 371-5
AB  - We investigated changes in vasoconstrictive function accompanying prolonged 
      nonpulsatile left heart bypass (NLHB). After 2-week pulsatile left heart bypass 
      (PLHB) in 11 goats, NLHB was conducted for another 4 weeks (Group N) in 6 goats. 
      In the other 5 goats, PLHB was continued for another 4 weeks (Group P). Systemic 
      vascular resistance at rest (rSVR) was measured on the last days of the second 
      and sixth postoperative week (W2 and W6, respectively). Subsequently, 
      phenylephrine was injected, and the maximum values (SVRmax) and the maximum 
      increasing change in SVR (DeltaSVR) were measured. No significant difference was 
      observed in rSVR between groups at W2 or W6. The SVRmax and the DeltaSVR at W2 
      were consistent in both groups. However, at W6, the SVRmax and the DeltaSVR of 
      Group N were significantly lower than those of Group P. In conclusion, prolonged 
      NLHB caused a significant decrease in the SVR response to phenylephrine, 
      indicating a dimunition of vasoconstrictive function.
FAU - Nishinaka, T
AU  - Nishinaka T
AD  - Department of Artificial Organs, National Cardiovascular Center Research 
      Institute, Osaka, Japan.
FAU - Tatsumi, E
AU  - Tatsumi E
FAU - Nishimura, T
AU  - Nishimura T
FAU - Shioya, K
AU  - Shioya K
FAU - Ohnishi, H
AU  - Ohnishi H
FAU - Taenaka, Y
AU  - Taenaka Y
FAU - Takano, H
AU  - Takano H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 0 (Vasoconstrictor Agents)
RN  - 11000-17-2 (Vasopressins)
RN  - 1WS297W6MV (Phenylephrine)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
CIN - Artif Organs. 2001 Dec;25(12):1022-4. PMID: 11843773
CIN - Artif Organs. 2002 Sep;26(9):812-3; author reply 813-5. PMID: 12197939
MH  - Animals
MH  - Blood Pressure
MH  - Goats
MH  - *Heart Bypass, Left
MH  - Heart-Assist Devices
MH  - Norepinephrine/blood
MH  - Phenylephrine/pharmacology
MH  - Renin/blood
MH  - Time Factors
MH  - Vascular Resistance/drug effects
MH  - *Vasoconstriction
MH  - Vasoconstrictor Agents/pharmacology
MH  - Vasopressins/blood
EDAT- 2001/06/14 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/14 10:00
PHST- 2001/06/14 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/14 10:00 [entrez]
AID - aor6778 [pii]
AID - 10.1046/j.1525-1594.2001.025005371.x [doi]
PST - ppublish
SO  - Artif Organs. 2001 May;25(5):371-5. doi: 10.1046/j.1525-1594.2001.025005371.x.