PMID- 11403932
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 305
IP  - 3
DP  - 2001 Jun 15
TI  - Enriched environment influences brain-derived neurotrophic factor levels in rat 
      forebrain after focal stroke.
PG  - 169-72
AB  - Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied 
      using enzyme immunoassay in different forebrain regions in the ipsi- and 
      contralateral hemispheres of rats housed under enriched or standard conditions 
      after the middle cerebral artery ligation. BDNF levels in the ipsilateral to 
      ligation side was significantly higher only in the frontal cortex of standard as 
      compared to enriched rats. However, BDNF overall was more abundant in standard 
      than in enriched group. In addition, BDNF levels detected in the hippocampus and 
      frontal cortex on the ischemic side of standard rats was higher as compared to 
      contralateral side. The present study shows that housing conditions after 
      permanent middle cerebral artery ligation leads to differential regulation of 
      BDNF protein levels in forebrain regions which might have important implication 
      for post-ischemic recovery.
FAU - Zhao, L R
AU  - Zhao LR
AD  - Division for Experimental Neurology, Wallenberg Neuroscience Center, BMC A-11, 
      University Hospital, SE-221 84, Lund, Sweden.
FAU - Risedal, A
AU  - Risedal A
FAU - Wojcik, A
AU  - Wojcik A
FAU - Hejzlar, J
AU  - Hejzlar J
FAU - Johansson, B B
AU  - Johansson BB
FAU - Kokaia, Z
AU  - Kokaia Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Environment
MH  - Frontal Lobe/metabolism
MH  - Hippocampus/metabolism
MH  - Housing, Animal
MH  - Immunoenzyme Techniques
MH  - Prosencephalon/*metabolism
MH  - Rats
MH  - Stroke/*metabolism
MH  - Tissue Distribution
EDAT- 2001/06/19 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/06/19 10:00
PHST- 2001/06/19 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/19 10:00 [entrez]
AID - S0304394001018377 [pii]
AID - 10.1016/s0304-3940(01)01837-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Jun 15;305(3):169-72. doi: 10.1016/s0304-3940(01)01837-7.