PMID- 11406695
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1930-6180 (Electronic)
IS  - 1084-2020 (Linking)
VI  - 40
IP  - 4
DP  - 1999 Sep
TI  - Role and Regulation of Chemokines in Rodent Models of Lung Inflammation.
PG  - 163-166
AB  - Acute inflammatory lung injury has been induced in rats by intrapulmonary 
      deposition of immunoglobulin G immune complexes or instillation of bacterial 
      lipopolysaccaride. Several juxtaposed cysteine residue (CXC) chemokines (e.g., 
      macrophage inflammatory protein 2 [MIP-2] and cytokine-induced neutrophil 
      chemoattractant [CINC]) and CC chemokines (MIP-1alpha, MIP-1Beta, and monocyte 
      chemoattractant protein-1 [MCP-1]) are upregulated in these acute injury models 
      and appear in substantial amounts in bronchoalveolar (BAL) fluids during the 
      inflammatory response. Antibody-induced blockade of either tumor necrosis factor 
      alpha (TNFalpha ) or the complement activation product C5a results in significant 
      reductions in BAL levels of chemokines, causing depressed inflammatory responses 
      and diminished lung injury. These data suggest that both TNFalpha (a product of 
      activated macrophages) and C5a participate as positive feedback mediators, 
      resulting in maximal expression of chemokines. These chemokines are involved in 
      recruitment of neutrophils and activation of tissue macrophages, the collective 
      products of which cause acute lung injury mediated by the generation of oxidants 
      and release of proteases.
FAU - Czermak, Boris J
AU  - Czermak BJ
AD  - Department of Trauma Surgery, University of Freiburg School of Medicine, 
      Freiburg/Breisgau, Germany.
FAU - Friedl, Hans P
AU  - Friedl HP
FAU - Ward, Peter A
AU  - Ward PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - ILAR J
JT  - ILAR journal
JID - 9516416
EDAT- 2001/06/15 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/06/15 10:00
PHST- 2001/06/15 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/06/15 10:00 [entrez]
AID - 10.1093/ilar.40.4.163 [doi]
PST - ppublish
SO  - ILAR J. 1999 Sep;40(4):163-166. doi: 10.1093/ilar.40.4.163.