PMID- 11407728
OWN - NLM
STAT- MEDLINE
DCOM- 20020207
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 65
IP  - 6
DP  - 2001 Jun
TI  - Serum thioredoxin (TRX) levels in patients with heart failure.
PG  - 491-4
AB  - An increase in oxidative stress is thought to be involved in the progression of 
      heart disease, but the serum level of thioredoxin (TRX), which regulates the 
      cellular redox state, has not been investigated in patients with heart diseases. 
      The present study determined serum TRX levels with a sandwich enzyme-linked 
      immunosorbent assay in a total of 39 patients with dilated cardiomyopathy (DCM) 
      (n=5), acute coronary syndrome (ACS) (n=7) or stable angina (n=18), including 
      effort angina (n=7) and vasospastic angina (n=11), and in control subjects (n=7). 
      The serum TRX level in patients with New York Heart Association (NYHA) functional 
      classes III and IV (n=8, 33.3+/-8.6 ng/ml) was significantly higher than in the 
      control subjects (n=7, 14.0+/-4.6 ng/ml). In addition, the serum TRX levels 
      correlated positively with the severity of NYHA class, and negatively with the 
      left ventricular ejection fraction. The serum TRX levels were elevated in 
      patients with ACS and DCM compared with the controls. These results indicate a 
      possible association between TRX concentration and the severity of heart failure.
FAU - Kishimoto, C
AU  - Kishimoto C
AD  - Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto 
      University, Japan. kkishi@kuhp.kyoto-u.ac.jp
FAU - Shioji, K
AU  - Shioji K
FAU - Nakamura, H
AU  - Nakamura H
FAU - Nakayama, Y
AU  - Nakayama Y
FAU - Yodoi, J
AU  - Yodoi J
FAU - Sasayama, S
AU  - Sasayama S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 52500-60-4 (Thioredoxins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/blood/etiology
MH  - Case-Control Studies
MH  - Coronary Disease/blood/etiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/*blood/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/physiology
MH  - Stroke Volume
MH  - Thioredoxins/*blood
MH  - Ventricular Dysfunction, Left
EDAT- 2001/06/16 10:00
MHDA- 2002/02/08 10:01
CRDT- 2001/06/16 10:00
PHST- 2001/06/16 10:00 [pubmed]
PHST- 2002/02/08 10:01 [medline]
PHST- 2001/06/16 10:00 [entrez]
AID - 10.1253/jcj.65.491 [doi]
PST - ppublish
SO  - Jpn Circ J. 2001 Jun;65(6):491-4. doi: 10.1253/jcj.65.491.