PMID- 11409978
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190723
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 49
IP  - 6
DP  - 2001 Jun
TI  - Uniformly (14)C-ring-labeled 2,4-dichlorophenoxyacetic acid: a metabolism study 
      in bluegill sunfish, Lepomis macrochirus.
PG  - 2853-9
AB  - The fate of 2,4-dichlorophenoxyacetic acid (2,4-D), a mixture of 
      [phenyl(U)-(14)C]-2,4-D and unlabeled 2,4-D, in bluegill sunfish was investigated 
      after exposure to approximately 11 ppm under static conditions for 4 days. Total 
      radioactive residues (TRR) in whole fish increased from 0.41 ppm on day 1 to 0.60 
      ppm on day 3. TRR levels in fillet (edible) and viscera (nonedible) of treated 
      fish on day 4 were 0.41 and 1.9 ppm, respectively. Most residues in both matrices 
      were acetonitrile soluble; small amounts were hexane soluble or unextractable 
      with solvents. Acid and base hydrolyses with ethyl acetate partitioning were used 
      to release the fillet unextractable residues. The identification of 2,4-D and 
      2,4-dichlorophenol (2,4-DCP) in the fillet was conclusively confirmed by GC-MS 
      analysis. On the basis of the experimental data from this study, a metabolic 
      pathway for 2,4-D in bluegill sunfish in which the 2,4-D is metabolized to 
      2,4-DCP and conjugates of 2,4-D and 2,4-DCP is proposed.
FAU - Barnekow, D E
AU  - Barnekow DE
AD  - ABC Laboratories, Inc., 7200 East ABC Lane, Columbia, Missouri 65205, USA. 
      debarnekow@dowagro.com
FAU - Premkumar, N D
AU  - Premkumar ND
FAU - Stewart, S
AU  - Stewart S
FAU - Hamburg, A W
AU  - Hamburg AW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Carbon Isotopes)
RN  - 0 (Pesticide Residues)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/*metabolism
MH  - Animals
MH  - Carbon Isotopes
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - Perciformes/*metabolism
MH  - Pesticide Residues/*analysis
MH  - Tissue Distribution
EDAT- 2001/06/21 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/06/21 10:00
PHST- 2001/06/21 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/06/21 10:00 [entrez]
AID - jf001294a [pii]
AID - 10.1021/jf001294a [doi]
PST - ppublish
SO  - J Agric Food Chem. 2001 Jun;49(6):2853-9. doi: 10.1021/jf001294a.