PMID- 11411342
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20190901
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 117
IP  - 5
DP  - 2001 May
TI  - [Role of central histamine in amygdaloid kindled seizures].
PG  - 329-34
AB  - The role of central histamine in amygdaloid kindled seizures in rats was studied. 
      Histamine content in the amygdala was significantly decreased after development 
      of amygdaloid kindling. Intracerebroventricular (i.c.v.) injection of histamine 
      resulted in inhibition of amygdaloid kindled seizures. The H1-agonists 
      2-methylhistamine and 2-thiazolylethylamine also inhibited amygdaloid kindled 
      seizures. In addition, intraperitoneal (i.p.) injection of histidine and 
      metoprine inhibited amygdaloid kindled seizures at doses that caused increases in 
      histamine contents of the brain. H1-antagonists (diphenhydramine and 
      chlorpheniramine) attenuated histamine- or histidine-induced inhibition of 
      amygdaloid kindled seizures. Both i.c.v. and i.p. injections of H3-antagonists 
      (thioperamide, AQ0145 and clobenpropit) resulted in a dose-related inhibition of 
      amygdaloid kindled seizures. The effects of thioperamide and AQ0145 were 
      inhibited by an H3-agonist (R)-alpha-methylhistamine and H1-antagonists. On the 
      other hand, H2-antagonists showed no antagonistic effect. GABAmimetic drugs, 
      diazepam, sodium valproate and muscimol potentiated the effect of clobenpropit. 
      Bicuculline caused significant antagonism of the inhibition of amygdaloid kindled 
      seizures induced by clobenpropit. These findings suggested that a histaminergic 
      mechanism plays an important role in suppressing amygdaloid kindled seizures 
      through histamine H1-receptors. In addition, an inhibition of amygdaloid kindled 
      seizures induced by histamine is closely related with the action of GABA.
FAU - Kamei, C
AU  - Kamei C
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama 
      University, Okayama 700-8530, Japan. kamei@pheasant.pharm.okayama-u.ac.jp
FAU - Okuma, C
AU  - Okuma C
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Histamine Antagonists)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Amygdala/drug effects/*physiology
MH  - Animals
MH  - Histamine/pharmacology/*physiology
MH  - Histamine Antagonists/pharmacology
MH  - Kindling, Neurologic/drug effects/*physiology
MH  - Rats
RF  - 37
EDAT- 2001/06/20 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - 10.1254/fpj.117.329 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 2001 May;117(5):329-34. doi: 10.1254/fpj.117.329.