PMID- 11411909
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190118
IS  - 0001-5555 (Print)
IS  - 0001-5555 (Linking)
VI  - 81
IP  - 1
DP  - 2001 Jan-Feb
TI  - No human leukocyte antigen-A, -B or -DR association in Swedish patients with 
      hidradenitis suppurativa.
PG  - 28-30
AB  - Hidradenitis suppurativa (HS) is a cicatrizing, inflammatory and recurrent 
      disease restricted to inverse skin, such as that of the axilla and groin of 
      younger adults. In a previous study, using serological tissue-typing techniques, 
      no significant increases in the human leukocyte antigen (HLA)-A and -B 
      specificities were found in patients with HS. The aim of this study was to 
      determine the frequencies of HLA-A, -B and, for the first time, HLA-DR alleles, 
      using genomic tissue-typing methods in patients with HS. Forty-two unrelated 
      Swedish patients with HS were included and compared with 250 controls. According 
      to clinical staging adopted from Hurley all of the patients had stage II HS, i.e. 
      recurrent abscesses with tract formation and cicatrization and single or multiple 
      widely separated lesions. No association with HLA-A, -B or -DRB1 alleles was 
      found in patients with HS. Genetic factors associated with the HLA class I or II 
      regions do not appear to contribute significantly to the possible genetic 
      susceptibility of HS.
FAU - Lapins, J
AU  - Lapins J
AD  - Department of Medicine, Karolinska Institutet, Huddinge University Hospital, 
      Sweden. jan.lapins@dermat.hs.sll.se
FAU - Olerup, O
AU  - Olerup O
FAU - Emtestam, L
AU  - Emtestam L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Testing
MH  - HLA-A Antigens/analysis/*genetics
MH  - HLA-B Antigens/analysis/*genetics
MH  - HLA-DR Antigens/analysis/*genetics
MH  - Hidradenitis Suppurativa/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Sweden
EDAT- 2001/06/20 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - 10.1080/00015550119053 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2001 Jan-Feb;81(1):28-30. doi: 10.1080/00015550119053.