PMID- 11412335
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20190921
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 13
IP  - 6
DP  - 2001 Jun
TI  - Anorexic but not pyrogenic actions of interleukin-1 are modulated by central 
      melanocortin-3/4 receptors in the rat.
PG  - 490-5
AB  - The cytokine interleukin-1 (IL-1), which mediates many responses to infection and 
      injury, induces anorexia and fever through direct actions in the central nervous 
      system. The melanocortin neuropeptides, such as alpha melanocyte-stimulating 
      hormone (alpha-MSH), reportedly antagonize many actions of IL-1, including fever 
      and anorexia. However, it is unknown whether endogenous melanocortins modulate 
      anorexia induced by IL-1. The objective of the present study was to establish the 
      effect of endogenous melanocortins on IL-1-induced anorexia and fever in the rat. 
      Intracerebroventricular (i.c.v.) injection of IL-1beta caused a significant 
      reduction in food intake and body weight gain, and a rise in core body 
      temperature in conscious rats. Coadministration of the melanocortin-3/4 receptor 
      (MC3/4-R) antagonist, SHU9119, reversed IL-1beta-induced reductions in food 
      intake and body weight, but did not affect the febrile response to IL-1beta. 
      These data suggest IL-1beta may elicit its effects on food intake through the 
      melanocortin system, predominantly via the MC3-R or MC4-R. In contrast, 
      IL-1beta-induced fever does not appear to be mediated or modulated by MC3-R or 
      MC4-R activity.
FAU - Lawrence, C B
AU  - Lawrence CB
AD  - School of Biological Sciences, 1.124 Stopford Building, University of Manchester, 
      Oxford Road, Manchester M13 9PT, UK. catherine.b.lawrence@man.ac.uk
FAU - Rothwell, N J
AU  - Rothwell NJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Appetite Depressants)
RN  - 0 (Interleukin-1)
RN  - 0 (Pyrogens)
RN  - 0 (Receptors, Corticotropin)
RN  - 0 (Receptors, Melanocortin)
RN  - 0 (alpha-MSH (4-10)amide, Ac-Nle(4)-cyclo(Asp(5)-Phe(7)-Lys(10))-)
RN  - 168482-23-3 (SHU 9119)
RN  - 581-05-5 (alpha-MSH)
RN  - 9002-79-3 (Melanocyte-Stimulating Hormones)
SB  - IM
MH  - Animals
MH  - Anorexia/chemically induced
MH  - Appetite Depressants/administration & dosage/*pharmacology
MH  - Body Temperature/drug effects
MH  - Brain/*drug effects/physiology
MH  - Eating/drug effects
MH  - Fever/chemically induced
MH  - Injections, Intraventricular
MH  - Interleukin-1/administration & dosage/*pharmacology
MH  - Kinetics
MH  - Male
MH  - Melanocyte-Stimulating Hormones/administration & dosage/pharmacology
MH  - Pyrogens/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Corticotropin/agonists/*physiology
MH  - Receptors, Melanocortin
MH  - Weight Loss/drug effects
MH  - alpha-MSH/administration & dosage/analogs & derivatives/pharmacology
EDAT- 2001/06/20 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - jne660 [pii]
AID - 10.1046/j.1365-2826.2001.00660.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2001 Jun;13(6):490-5. doi: 10.1046/j.1365-2826.2001.00660.x.