PMID- 11412342
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20190921
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 13
IP  - 6
DP  - 2001 Jun
TI  - Maternal odours induce Fos in the main but not the accessory olfactory bulbs of 
      neonatal male and female ferrets.
PG  - 551-60
AB  - Previous research demonstrated that exposing gonadectomized adult ferrets to 
      odours in oestrous female bedding induced nuclear Fos-immunoreactivity (Fos-IR; a 
      marker of neuronal activity) in the main as opposed to the accessory olfactory 
      system in a sexually dimorphic fashion, which was further augmented in both sexes 
      by treatment with testosterone propionate. Ferrets are born in an altricial state 
      and presumably use maternal odour cues to locate the nipples until the eyes open 
      after postnatal (P) day 23. We investigated whether maternal odours augment 
      neuronal Fos preferentially in the main versus accessory olfactory system of 
      neonatal male and female ferret kits. Circulating testosterone levels peak in 
      male ferrets on postnatal day P15, and mothers provide maximal anogenital 
      stimulation (AGS) to males at this same age. Therefore, we assessed the ability 
      of maternal odours to augment Fos-IR in the accessory olfactory bulb (AOB), the 
      main olfactory bulb (MOB) and other forebrain regions of male and female ferret 
      kits on P15 and investigated whether artificial AGS (provided with a paintbrush) 
      would further enhance any effects of maternal odours. After separation from their 
      mothers for 4 h, groups of male and female kits that were placed for 1.5 h with 
      their anaesthetized mother had significantly more Fos-IR cells in the MOB granule 
      cell layer and in the anterior-cortical amygdala, but not in the AOB cell layer, 
      compared to control kits that were left on the heating pad. Artificial AGS failed 
      to amplify these effects of maternal odours. Maternal odours (with or without 
      concurrent AGS) failed to augment neuronal Fos-IR in medial amygdaloid and 
      hypothalamic regions that are activated in adult ferrets by social odours. In 
      neonatal ferrets of both sexes, as in adults, socially relevant odours are 
      detected by the main olfactory epithelium and initially processed by the MOB and 
      the anterior-cortical amygdala. In neonates, unlike adults, medial amygdaloid and 
      hypothalamic neurones either do not respond to these inputs or respond in a 
      manner that fails to induce Fos expression.
FAU - Chang, Y M
AU  - Chang YM
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Kelliher, K R
AU  - Kelliher KR
FAU - Baum, M J
AU  - Baum MJ
LA  - eng
GR  - HD 21094/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Female
MH  - Ferrets/*physiology
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Mothers
MH  - Neurons/metabolism
MH  - *Odorants
MH  - Olfactory Bulb/*metabolism
MH  - Preoptic Area/metabolism
MH  - Proto-Oncogene Proteins c-fos/analysis/*biosynthesis
MH  - Testosterone/blood
EDAT- 2001/06/20 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - jne670 [pii]
AID - 10.1046/j.1365-2826.2001.00670.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2001 Jun;13(6):551-60. doi: 10.1046/j.1365-2826.2001.00670.x.