PMID- 11413085
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20190623
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 103
IP  - 24
DP  - 2001 Jun 19
TI  - Differential effects of nifedipine and co-amilozide on the progression of early 
      carotid wall changes.
PG  - 2949-54
AB  - BACKGROUND: Common carotid artery intima-media thickness (IMT) progression was 
      compared between 4 years of treatment with nifedipine and diuretic. METHODS AND 
      RESULTS: This study, ancillary to the International Nifedipine GITS Study: 
      Intervention as a Goal in Hypertension Treatment (INSIGHT), involved nifedipine 
      30 mg or co-amilozide (hydrochlorothiazide 25 mg and amiloride 2.5 mg) with 
      optional subsequent titration. Among 439 randomized hypertensive patients, 324 
      had >/=1 year of follow-up (intent-to-treat group), and 242 completed follow-up 
      (until-end-of-study group). Ultrasonography was performed at baseline, 4 months 
      later, and then every year. Central computerized reading provided far-wall IMT, 
      diameter, and cross-sectional area IMT (CSA-IMT). The primary outcome was IMT 
      progression rate (slope of IMT-time regression). Secondary outcomes were changes 
      from baseline (Delta) in IMT, diameter, and CSA-IMT. In the until-end-of-study 
      population, between-treatment differences existed in IMT progression rate 
      (P=0.002), Delta IMT (P=0.001), and Delta CSA-IMT (P=0.006), because IMT 
      progressed on co-amilozide but not on nifedipine. In the intent-to-treat 
      population, treatment differences existed in Delta IMT (P=0.004) and Delta 
      CSA-IMT (P=0.04) but not in IMT progression rate (P=0.09). Patients with >/=2, 3, 
      or 4 years of follow-up showed treatment differences in IMT progression rate 
      (P=0.04, 0.004, 0.007, respectively), Delta IMT (P=0.005, 0.001, 0.005), and 
      Delta CSA-IMT (P=0.025, 0.013, 0.015). Diameter decreased more on co-amilozide 
      than on nifedipine in the intent-to-treat population (P<0.05), whereas blood 
      pressure decreased similarly on both treatments. CONCLUSIONS: A difference in 
      early carotid wall changes is shown between 2 equally effective antihypertensive 
      treatments.
FAU - Simon, A
AU  - Simon A
AD  - Centre de Medecine Preventive Cardiovasculaire, Hopital Broussais, Paris, France. 
      alain.simon@brs.ap-hop-paris.fr
FAU - Gariepy, J
AU  - Gariepy J
FAU - Moyse, D
AU  - Moyse D
FAU - Levenson, J
AU  - Levenson J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Diuretics)
RN  - 0 (Drug Combinations)
RN  - 0 (Vasodilator Agents)
RN  - 0J48LPH2TH (Hydrochlorothiazide)
RN  - 50VV3VW0TI (Atenolol)
RN  - 68529-45-3 (amiloride, hydrochlorothiazide drug combination)
RN  - 69PN84IO1A (Enalapril)
RN  - 7DZO8EB0Z3 (Amiloride)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amiloride/*therapeutic use
MH  - Antihypertensive Agents/therapeutic use
MH  - Atenolol/therapeutic use
MH  - Blood Pressure/drug effects
MH  - Carotid Artery, Common/diagnostic imaging/*drug effects/pathology
MH  - Carotid Stenosis/complications/*diagnosis/pathology
MH  - Disease Progression
MH  - Diuretics/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Drug Therapy, Combination
MH  - Enalapril/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - France
MH  - Humans
MH  - Hydrochlorothiazide/*therapeutic use
MH  - Hypertension/complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Nifedipine/*therapeutic use
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Vasodilator Agents/therapeutic use
EDAT- 2001/06/20 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - 10.1161/01.cir.103.24.2949 [doi]
PST - ppublish
SO  - Circulation. 2001 Jun 19;103(24):2949-54. doi: 10.1161/01.cir.103.24.2949.