PMID- 11413408
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20190915
IS  - 0277-3740 (Print)
IS  - 0277-3740 (Linking)
VI  - 20
IP  - 5
DP  - 2001 Jul
TI  - Thermal consequences of photorefractive keratectomy.
PG  - 509-15
AB  - PURPOSE: Photorefractive keratectomy (PRK) is still a widely used method for the 
      correction of refractive error despite the advent of laser in situ keratomileusis 
      (LASIK). However, both procedures are associated with significant side effects 
      such as corneal haze and regression. Several factors have been implicated in the 
      etiology of haze, one of which is thermal loading of the cornea. The purpose of 
      this study was to investigate the temperature changes occurring during PRK when 
      performed at different ablation depths. METHODS: Noncontact, color-coded ocular 
      thermography was performed with an infrared detector apparatus during PRK 
      ablation on 19 ovine corneas. Five different refractive corrections were carried 
      out ranging from -2.00 diopters (D) (ablation depth, 31.2 microm) to -10.00 D 
      (ablation depth, 137.9 microm). RESULTS: A temperature rise at the corneal 
      surface was demonstrated in all 19 corneas. The mean rise in temperature was 7.35 
      +/- 1.13 degrees C with a maximum rise in temperature of 8.97 degrees C. A 
      positive correlation was found between the refractive correction and the peak 
      rise in temperature (r2 = 0.57, p< 0.0001). The rate of temperature change was 
      greater for smaller treatments than for larger treatments (r2 = 0.79, p < 
      0.0001). Corneas undergoing larger treatments were subject to greater rises in 
      temperature for longer periods of time. CONCLUSIONS: This study suggests that the 
      cornea undergoes a significant rise in temperature as a result of the PRK 
      process. Further investigation is required to determine what effect this thermal 
      loading has on the corneal wound healing response after PRK.
FAU - Maldonado-Codina, C
AU  - Maldonado-Codina C
AD  - Eurolens Research, Department of Optometry and Neuroscience, Manchester, United 
      Kingdom. c.m-codina@umist.ac.uk
FAU - Morgan, P B
AU  - Morgan PB
FAU - Efron, N
AU  - Efron N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Animals
MH  - *Body Temperature
MH  - Cornea/*surgery
MH  - Corneal Opacity/etiology
MH  - Hot Temperature/*adverse effects
MH  - Lasers, Excimer
MH  - Photorefractive Keratectomy/*adverse effects
MH  - Refractive Surgical Procedures
MH  - Sheep
MH  - Thermography
MH  - Wound Healing
EDAT- 2001/06/20 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/06/20 10:00
PHST- 2001/06/20 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/06/20 10:00 [entrez]
AID - 10.1097/00003226-200107000-00014 [doi]
PST - ppublish
SO  - Cornea. 2001 Jul;20(5):509-15. doi: 10.1097/00003226-200107000-00014.