PMID- 11414745
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20161019
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 100
IP  - 1
DP  - 2001 Jul
TI  - Cytokine and chemokine dysregulation in hyper-IgE syndrome.
PG  - 49-56
AB  - Hyper-IgE syndrome is characterized by severe recurrent staphylococcal 
      infections, eczema, bone abnormalities, and markedly elevated levels of 
      immunoglobulin E (IgE). The genetic basis is not known and the central 
      immunologic defect is largely undefined. Reduced neutrophil chemotaxis is often 
      described, and variable T cell defects have been demonstrated in some patients. 
      It has been hypothesized that hyper-IgE is associated with a Th1/Th2 imbalance. 
      We wished to characterize cytokine and chemokine imbalances that might reflect 
      the underlying disease process or reflect ongoing pathologic processes. Nine 
      patients with hyper-IgE syndrome and six controls were studied. 
      Radioimmunoassays, flow cytometry, and gene array analyses were performed to 
      characterize cytokine and chemokine production. Hyper-IgE patients express more 
      IL-12, while ENA-78, MCP-3, and eotaxin are markedly underexpressed. 
      Underexpression of a set of chemokines could explain a number of features of 
      hyper-IgE syndrome and may offer a new paradigm for the understanding of this 
      disorder.
CI  - Copyright 2001 Academic Press.
FAU - Chehimi, J
AU  - Chehimi J
AD  - The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
FAU - Elder, M
AU  - Elder M
FAU - Greene, J
AU  - Greene J
FAU - Noroski, L
AU  - Noroski L
FAU - Stiehm, E R
AU  - Stiehm ER
FAU - Winkelstein, J A
AU  - Winkelstein JA
FAU - Sullivan, K E
AU  - Sullivan KE
LA  - eng
GR  - R01 AI044127/AI/NIAID NIH HHS/United States
GR  - A127551/PHS HHS/United States
GR  - M01 RR01271/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (CCL11 protein, human)
RN  - 0 (CCL7 protein, human)
RN  - 0 (CXCL5 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL7)
RN  - 0 (Chemokine CXCL5)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cytokines)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-8)
RN  - 0 (Interleukins)
RN  - 0 (Monocyte Chemoattractant Proteins)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SPP1 protein, human)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 106441-73-0 (Osteopontin)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cells, Cultured/drug effects
MH  - Chemokine CCL11
MH  - Chemokine CCL7
MH  - Chemokine CXCL5
MH  - Chemokines/*biosynthesis/genetics
MH  - *Chemokines, CC
MH  - *Chemokines, CXC
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*biosynthesis/genetics
MH  - DNA, Complementary/genetics
MH  - *Gene Expression Regulation/drug effects
MH  - Humans
MH  - Interferon-gamma/biosynthesis/genetics
MH  - Interleukin-12/biosynthesis/genetics
MH  - Interleukin-8/analogs & derivatives/biosynthesis/genetics
MH  - Interleukins/biosynthesis/genetics
MH  - Job Syndrome/genetics/immunology/*metabolism
MH  - Lymphocyte Activation/drug effects
MH  - Monocyte Chemoattractant Proteins/biosynthesis/genetics
MH  - Nicotinamide Phosphoribosyltransferase
MH  - Osteopontin
MH  - Phytohemagglutinins/pharmacology
MH  - RNA, Messenger/biosynthesis
MH  - Receptor, trkA/biosynthesis/genetics
MH  - Sialoglycoproteins/biosynthesis/genetics
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Th1 Cells/drug effects/immunology
MH  - Th2 Cells/drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis/genetics
EDAT- 2001/06/21 10:00
MHDA- 2001/08/17 10:01
CRDT- 2001/06/21 10:00
PHST- 2001/06/21 10:00 [pubmed]
PHST- 2001/08/17 10:01 [medline]
PHST- 2001/06/21 10:00 [entrez]
AID - S1521-6616(01)95039-9 [pii]
AID - 10.1006/clim.2001.5039 [doi]
PST - ppublish
SO  - Clin Immunol. 2001 Jul;100(1):49-56. doi: 10.1006/clim.2001.5039.