PMID- 11414776
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20220408
IS  - 1356-689X (Print)
IS  - 1356-689X (Linking)
VI  - 6
IP  - 2
DP  - 2001 May
TI  - Cervical mobilisation: concurrent effects on pain, sympathetic nervous system 
      activity and motor activity.
PG  - 72-81
AB  - Recent findings that spinal manual therapy (SMT) produces concurrent hypoalgesic 
      and sympathoexcitatory effects have led to the proposal that SMT may exert its 
      initial effects by activating descending inhibitory pathways from the dorsal 
      periaqueductal gray area of the midbrain (dPAG). In addition to hypoalgesic and 
      sympathoexcitatory effects, stimulation of the dPAG in animals has been shown to 
      have a facilitatory effect on motor activity. This study sought to further 
      investigate the proposal regarding SMT and the PAG by including a test of motor 
      function in addition to the variables previously investigated. Using a condition 
      randomised, placebo-controlled, double blind, repeated measures design, 30 
      subjects with mid to lower cervical spine pain of insidious onset participated in 
      the study. The results indicated that the cervical mobilisation technique 
      produced a hypoalgesic effect as revealed by increased pressure pain thresholds 
      on the side of treatment (P=0.0001) and decreased resting visual analogue scale 
      scores (P=0.049). The treatment technique also produced a sympathoexcitatory 
      effect with an increase in skin conductance (P<0.002) and a decrease in skin 
      temperature (P=<0.02). There was a decrease in superficial neck flexor muscle 
      activity (P<0.0002) at the lower levels of a staged cranio-cervical flexion test. 
      This could imply facilitation of the deep neck flexor muscles with a decreased 
      need for co-activation of the superficial neck flexors. The combination of all 
      findings would support the proposal that SMT may, at least initially, exert part 
      of its influence via activation of the PAG.
CI  - Copyright 2000 Harcourt Publishers Ltd.
FAU - Sterling, M
AU  - Sterling M
AD  - Department of Physiotherapy, University of Queensland, St Lucia, Australia.
FAU - Jull, G
AU  - Jull G
FAU - Wright, A
AU  - Wright A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Man Ther
JT  - Manual therapy
JID - 9610924
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cervical Vertebrae
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - *Manipulation, Spinal
MH  - Motor Activity/*physiology
MH  - *Pain Management
MH  - Periaqueductal Gray/*physiology
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
MH  - Sympathetic Nervous System/*physiology
EDAT- 2001/06/21 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/06/21 10:00
PHST- 2001/06/21 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/06/21 10:00 [entrez]
AID - S1356-689X(00)90378-3 [pii]
AID - 10.1054/math.2000.0378 [doi]
PST - ppublish
SO  - Man Ther. 2001 May;6(2):72-81. doi: 10.1054/math.2000.0378.