PMID- 11416994
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20191104
IS  - 1083-7450 (Print)
IS  - 1083-7450 (Linking)
VI  - 6
IP  - 2
DP  - 2001
TI  - Effervescent atomization of aqueous polymer solutions and dispersions.
PG  - 201-10
AB  - The purpose of this paper is to characterize the performance of effervescent 
      atomizers via the effects of Air-to-Liquid-Mass-Ratio, (ALMR), feed pressure, and 
      liquid viscosity on spray droplet size. Water and aqueous solutions having 
      varying concentrations of polyvinylpyrrolidone, (PVP), (Kollidon 30, 90, and the 
      copolymer VA 64), hydroxypropyl methylcellulose, (HPMC), (Pharmacoat 603, 606, 
      and 615), and aqueous polymethacrylate dispersions, (Eudragit RS 30 D, RL 30 D, 
      and L 30 D-55) were sprayed over a range of ALMRs from approximately 0.1 to 0.8 
      at feed pressures ranging from approximately 550 to 1590 kPa. Fluid viscosities 
      ranged from 1 to 228 mPa.s. The ALMR of the spray was shown to be the most 
      important factor influencing the Sauter mean diameter (SMD) of the droplets, 
      while feed pressure was shown to have only a minor effect on droplet size. Sprays 
      with SMDs between 7 and 12 microns were produced for the polymethacrylates, 13 to 
      24 microns for the PVPs, and 15 to 20 microns for the HPMCs, all at an ALMR of 
      0.4 and a feed pressure of 1172 kPa. A higher liquid viscosity lead to larger 
      droplets. The correlation between viscosity and droplet size was found to be 
      dependent on the type of polymer.
FAU - Petersen, F J
AU  - Petersen FJ
AD  - Department of Pharmaceutics, Royal Danish School of Pharmacy, Universitetsparken 
      2, DK-2100 Copenhagen, Denmark. fjp@dfh.dk
FAU - Worts, O
AU  - Worts O
FAU - Schaefer, T
AU  - Schaefer T
FAU - Sojka, P E
AU  - Sojka PE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Dev Technol
JT  - Pharmaceutical development and technology
JID - 9610932
RN  - 0 (Solutions)
RN  - 3NXW29V3WO (Hypromellose Derivatives)
RN  - 9004-67-5 (Methylcellulose)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Hypromellose Derivatives
MH  - Methylcellulose/administration & dosage/analogs & derivatives
MH  - Particle Size
MH  - Povidone/administration & dosage
MH  - Solutions
MH  - *Technology, Pharmaceutical
MH  - Viscosity
EDAT- 2001/06/22 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/06/22 10:00
PHST- 2001/06/22 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/06/22 10:00 [entrez]
AID - 10.1081/pdt-100000737 [doi]
PST - ppublish
SO  - Pharm Dev Technol. 2001;6(2):201-10. doi: 10.1081/pdt-100000737.