PMID- 11417483
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 15
IP  - 6
DP  - 2001 Jun
TI  - Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and 
      progression to acute myelogenous leukemia.
PG  - 954-62
AB  - Deletions or monosomy of chromosomes 5 and 7 are frequently observed in 
      myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). In this 
      study two genes, PURA and PURB, encoding functionally cooperative proteins in the 
      Pur family, are localized to chromosome bands 5q31.1 and 7p13, respectively. One 
      or both of these loci are shown to be hemizygously deleted in 60 MDS or AML 
      patients using fluorescence in situ hybridization (FISH). High-resolution mapping 
      of PURA localizes it approximately 1.1 Mb telomeric to the EGR-1 gene. Frequency 
      of PURA deletion and segregation with EGR-1 indicate that PURA is within the most 
      commonly deleted segment in myeloid disorders characterized by del(5)(q31). No 
      mutations have been detected within the coding sequence of PURA. Concurrent 
      deletions of PURA and PURB occur in MDS at a rate nearly 1.5-fold higher than 
      statistically expected and in AML at a rate > 5-fold higher. This novel 
      simultaneous deletion of two closely related gene family members may thus have 
      consequences related to progression to AML. Pur alpha, an Rb-binding protein, has 
      been implicated in cell cycle control and differentiation, and Pur alpha and Pur 
      beta are reported to function as heterodimers. Alterations in these genes could 
      affect a delicate balance critical in myeloid development.
FAU - Lezon-Geyda, K
AU  - Lezon-Geyda K
AD  - Department of Pathology, Biochemistry and Molecular Biology, Derald H Ruttenberg 
      Cancer Center, New York, NY, USA.
FAU - Najfeld, V
AU  - Najfeld V
FAU - Johnson, E M
AU  - Johnson EM
LA  - eng
GR  - CA55219/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (EGR1 protein, human)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, mouse)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PURA protein, human)
RN  - 0 (PURB protein, human)
RN  - 0 (Pura protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Transformation, Neoplastic/genetics
MH  - Child, Preschool
MH  - Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Bacterial
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Cyclic AMP Response Element-Binding Protein/*genetics
MH  - DNA, Neoplasm/genetics
MH  - DNA-Binding Proteins/*deficiency/genetics
MH  - Disease Progression
MH  - Early Growth Response Protein 1
MH  - Female
MH  - *Gene Deletion
MH  - Gene Library
MH  - Genotype
MH  - Humans
MH  - *Immediate-Early Proteins
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics/pathology
MH  - Loss of Heterozygosity
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Neoplasm Proteins/deficiency/genetics
MH  - Nerve Tissue Proteins
MH  - Polymerase Chain Reaction
MH  - Transcription Factors/deficiency/genetics
MH  - Translocation, Genetic
EDAT- 2001/06/22 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/22 10:00
PHST- 2001/06/22 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/22 10:00 [entrez]
AID - 10.1038/sj.leu.2402108 [doi]
PST - ppublish
SO  - Leukemia. 2001 Jun;15(6):954-62. doi: 10.1038/sj.leu.2402108.