PMID- 11418473
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20220316
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 98
IP  - 1
DP  - 2001 Jul 1
TI  - Surgical and physical stress increases circulating blood dendritic cell counts 
      independently of monocyte counts.
PG  - 140-5
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells that have the 
      unique ability to initiate a primary immune response. The effect of physiologic 
      stress on circulating blood DCs has thus far not been studied. In this study, we 
      applied a recently developed method of counting blood DCs to test the hypothesis 
      that significant stress to the body such as surgery and exercise might induce 
      measurable changes in the DC numbers, subsets, phenotype, and function. 
      Twenty-six patients scheduled for elective laparoscopic cholecystectomy, 4 for 
      elective hysterectomy, 56 controls, and 5 volunteers who underwent a stress 
      exercise test were enrolled in the study. Absolute DC counts increased acutely 
      (71.7% +/- 11% [SEM], P =.0001) in response to the stress of surgery and dropped 
      below preoperative levels (-25% +/- 14% [SEM], P =.05) on days 2-3. The 
      perioperative DC subset balance remained constant. Interestingly, DC counts 
      changed independently of monocyte counts. Exercise also induced a rise in DC 
      counts but coincidentally with monocyte counts. Surprisingly, no phenotypic or 
      functional activation of DCs was seen in either stress situations in vivo. DCs 
      are rapidly mobilized into the circulation in response to surgical and exercise 
      stress, which may serve to prepare the host's immune defenses against trauma. The 
      independent regulation of the DC and monocyte counts reinforces the distinction 
      between these 2 cell populations.
FAU - Ho, C S
AU  - Ho CS
AD  - Dendritic Cell Laboratory, Mater Medical Research Institute, University of 
      Queensland, Australia.
FAU - Lopez, J A
AU  - Lopez JA
FAU - Vuckovic, S
AU  - Vuckovic S
FAU - Pyke, C M
AU  - Pyke CM
FAU - Hockey, R L
AU  - Hockey RL
FAU - Hart, D N
AU  - Hart DN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Cell Count
MH  - Blood Circulation
MH  - Case-Control Studies
MH  - Dendritic Cells/*cytology
MH  - Elective Surgical Procedures/adverse effects/psychology
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*cytology
MH  - Stress, Physiological/*blood
EDAT- 2001/06/22 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/06/22 10:00
PHST- 2001/06/22 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/06/22 10:00 [entrez]
AID - S0006-4971(20)46903-4 [pii]
AID - 10.1182/blood.v98.1.140 [doi]
PST - ppublish
SO  - Blood. 2001 Jul 1;98(1):140-5. doi: 10.1182/blood.v98.1.140.