PMID- 11419891
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 37
IP  - 8
DP  - 2001 Jun 15
TI  - Skeletal muscle mass independently predicts peak oxygen consumption and 
      ventilatory response during exercise in noncachectic patients with chronic heart 
      failure.
PG  - 2080-5
AB  - OBJECTIVES: We sought to assess whether skeletal muscle mass might be a predictor 
      of peak oxygen consumption (Vo2) and relation of the ventilation to carbon 
      dioxide production (VE/VCo2) slope in patients with chronic heart failure (CHF) 
      independent of clinical conditions, neurohormonal activation and resting 
      hemodynamics. BACKGROUND: A variety of abnormalities characterize skeletal muscle 
      and contribute to exercise intolerance in patients with CHF. Skeletal muscle mass 
      is a determinant of peak Vo2 both in healthy patients and in patients with CHF, 
      but there are no reports on the independent predictive value of this parameter, 
      which can be measured with great accuracy by whole-body dual energy X-ray 
      absorptiometry (DEXA). The influence of skeletal muscle mass on VE/VCo2 slope is 
      not known either. METHODS: We prospectively evaluated 120 consecutive 
      noncachectic patients with CHF. Every patient underwent a cardiopulmonary 
      exercise test, an echo-Doppler examination and an evaluation of neurohormonal 
      activation and body composition as assessed by DEXA. RESULTS: At the univariate 
      analysis, New York Heart Association (NYHA) class (p < 0.0001), age (p < 0.0001), 
      male gender (p < 0.0001) and plasma renin (p < 0.0001) significantly related with 
      peak Vo2. There was a significant correlation between lean mass and absolute peak 
      Vo2 (r = 0.70, p < 0.0001) and VE/VCo2 slope (r = -0.27; p < 0.01). At the 
      multivariate analysis, lean mass predicted peak Vo2 and VE/VCo2 slope 
      independently of NYHA functional class, age, gender, neurohormonal activation and 
      resting hemodynamics. CONCLUSIONS: Skeletal muscle mass is an independent 
      predictor of peak Vo2 and VE/VCo2 slope in stable noncachectic patients with CHF. 
      Future studies will determine whether an increase in skeletal muscle mass in the 
      individual patient might result in an improvement in parameters of exercise 
      capacity.
FAU - Cicoira, M
AU  - Cicoira M
AD  - Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy. 
      mariantonietta.cicoira@univr.it
FAU - Zanolla, L
AU  - Zanolla L
FAU - Franceschini, L
AU  - Franceschini L
FAU - Rossi, A
AU  - Rossi A
FAU - Golia, G
AU  - Golia G
FAU - Zamboni, M
AU  - Zamboni M
FAU - Tosoni, P
AU  - Tosoni P
FAU - Zardini, P
AU  - Zardini P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Aged
MH  - Body Composition
MH  - Exercise/*physiology
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*physiopathology
MH  - *Oxygen Consumption
MH  - Prospective Studies
EDAT- 2001/06/23 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/23 10:00
PHST- 2001/06/23 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/23 10:00 [entrez]
AID - S0735-1097(01)01306-7 [pii]
AID - 10.1016/s0735-1097(01)01306-7 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2001 Jun 15;37(8):2080-5. doi: 10.1016/s0735-1097(01)01306-7.