PMID- 11420063
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 69
IP  - 1-2
DP  - 2001 May-Jun
TI  - GABA(A) but not GABA(B) receptor stimulation induces antianxiety profile in rats.
PG  - 9-15
AB  - The effect of GABA receptor agonists and antagonists on anxiety behavior in rats 
      in the elevated-plus-maze has been investigated. The increase in two parameters 
      of %open arm entries (%OAE) and %time spent in the open arms (%OAT) and decrease 
      in the %time spent in closed arm (%CAT) was considered as antianxiety effects. 
      Intracerebroventricular (i.c.v.) injection of different doses of the GABA(A) 
      receptor agonist muscimol (0.25, 0.5, and 1 microg/rat) increased %OAE and %OAT 
      and decreased %CAT in rats dose-dependently. The higher response was obtained 
      with 1 microg/rat of the drug. Neither icv (0.05, 0.1, and 0.2 microg/rat) nor 
      intraperitoneal (i.p.) (1, 2, and 4 mg/kg) injection of the GABA(B) receptor 
      agonist baclofen altered %OAE, %OAT, and %CAT. However, the GABA(B) receptor 
      antagonist CGP35348 (5, 10, and 30 microg/rat i.c.v.) increased %OAE and %OAT and 
      decreased %CAT in the animals. The response induced by injection of muscimol (0.5 
      microg/rat i.c.v.) or administration of CGP35348 (10 microg/rat i.c.v.) was 
      reduced by i.c.v. (1, 2, and 4 microg/rat) or i.p. (0.25, 0.5, and 0.75 mg/kg) 
      injection of the GABA(A) receptor antagonist bicuculline, except the effect of 
      CGP35348 on %CAT which was not significantly altered by i.p. administration of 
      bicuculline. Ip but not i.c.v. administration of bicuculline by itself reduced 
      both %OAE and %OAT but did not alter %CAT. None of the drugs altered the 
      locomotor activity of the animals. The current findings support our hypothesis 
      that the anxiolytic effects of GABA(B) antagonist are mediated by autoreceptor 
      blockade-induced release of endogenous GABA, which in turn activates postsynaptic 
      GABA(A) receptors.
FAU - Zarrindast, M
AU  - Zarrindast M
AD  - Department of Pharmacology, Medical School, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Rostami, P
AU  - Rostami P
FAU - Sadeghi-Hariri, M
AU  - Sadeghi-Hariri M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (GABA Agonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (GABA-A Receptor Agonists)
RN  - 0 (GABA-B Receptor Agonists)
RN  - 0 (Organophosphorus Compounds)
RN  - 2763-96-4 (Muscimol)
RN  - 87TI61875H (CGP 35348)
RN  - H789N3FKE8 (Baclofen)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Anxiety/psychology
MH  - Baclofen/pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Bicuculline/administration & dosage/pharmacology
MH  - GABA Agonists/*pharmacology
MH  - GABA Antagonists/administration & dosage/pharmacology
MH  - *GABA-A Receptor Agonists
MH  - *GABA-B Receptor Agonists
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Muscimol/administration & dosage/pharmacology
MH  - Organophosphorus Compounds/pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2001/06/23 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/06/23 10:00
PHST- 2001/06/23 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/06/23 10:00 [entrez]
AID - S0091305701005184 [pii]
AID - 10.1016/s0091-3057(01)00518-4 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):9-15. doi: 
      10.1016/s0091-3057(01)00518-4.