PMID- 11420726
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20061115
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 20
IP  - 24
DP  - 2001 May 28
TI  - Avian erythroleukemia: a model for corepressor function in cancer.
PG  - 3100-9
AB  - Transcriptional regulation at the level of chromatin plays crucial roles during 
      eukaryotic development and differentiation. A plethora of studies revealed that 
      the acetylation status of histones is controlled by multi-protein complexes 
      containing (de)acetylase activities. In the current model, histone deacetylases 
      and acetyltransferases are recruited to chromatin by DNA-bound repressors and 
      activators, respectively. Shifting the balance between deacetylation, i.e. 
      repressive chromatin and acetylation, i.e. active chromatin can lead to aberrant 
      gene transcription and cancer. In human acute promyelocytic leukemia (APL) and 
      avian erythroleukemia (AEL), chromosomal translocations and/or mutations in 
      nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded 
      oncoproteins that deregulate transcription and alter chromatin structure. The 
      oncogenic receptors are locked in their 'off' mode thereby constitutively 
      repressing transcription of genes that are critical for differentiation of 
      hematopoietic cells. AEL involves an oncogenic version of the chicken TRalpha, 
      v-ErbA. Apart from repression by v-ErbA via recruitment of corepressor complexes, 
      other repressors and corepressors appear to be involved in repression of v-ErbA 
      target genes, such as carbonic anhydrase II (CAII). Reactivation of repressed 
      genes in APL and AEL by chromatin modifying agents such as inhibitors of histone 
      deacetylase or of methylation provides new therapeutic strategies in the 
      treatment of acute myeloid leukemia.
FAU - Rietveld, L E
AU  - Rietveld LE
AD  - Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 
      6500 HB Nijmegen, The Netherlands.
FAU - Caldenhoven, E
AU  - Caldenhoven E
FAU - Stunnenberg, H G
AU  - Stunnenberg HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Alpharetrovirus
MH  - Animals
MH  - Avian Leukosis/*genetics/virology
MH  - Chickens
MH  - Gene Expression Regulation
MH  - Humans
MH  - Leukemia, Erythroblastic, Acute/genetics/virology
MH  - Models, Biological
MH  - Neoplasms/genetics
MH  - Repressor Proteins/physiology
MH  - Retroviridae Infections/*genetics/virology
RF  - 123
EDAT- 2001/06/23 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/06/23 10:00
PHST- 2001/06/23 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/06/23 10:00 [entrez]
AID - 10.1038/sj.onc.1204335 [doi]
PST - ppublish
SO  - Oncogene. 2001 May 28;20(24):3100-9. doi: 10.1038/sj.onc.1204335.