PMID- 11421494
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20170214
IS  - 0192-6233 (Print)
IS  - 0192-6233 (Linking)
VI  - 29
IP  - 2
DP  - 2001 Mar-Apr
TI  - Pulmonary function in nonsmokers following exposure to sidestream cigarette 
      smoke.
PG  - 260-4
AB  - Ten healthy male and 10 healthy female, "never-smoking" subjects (ages 21-50) 
      participated in a 5-day environmental room study to determine if an acute 
      exposure to a high level of fresh diluted sidestream smoke (FDSS) would alter 
      pulmonary function. On Monday, Tuesday, Thursday and Friday, the twenty subjects 
      sat in an environmental room for 7.33 hours and were exposed to filtered and 
      humidified air. On Wednesday, the twenty subjects were exposed in an 
      environmental room for 7.33 hours to an average respirable suspended particle 
      (RSP) concentration of 179 micrograms per m3 of FDSS generated by machine smoking 
      Kentucky 1R4F reference cigarettes. This level of FDSS is 3.3 times the 95th 
      percentile concentration of workplace environmental tobacco smoke exposure levels 
      previously measured in the US. FVC and FEV1 decreased approximately 1.6% (p < 
      0.05) in both males and females after exposure. Similarly, PEF decreased 
      approximately 1.3% (p < 0.03) following exposure. The observed decrease in 
      pulmonary function was consistent with a "stress" related norepinephrine-induced 
      alteration in blood flow leading to transient bronchoconstriction. Alternatively, 
      a cholinergic reflex due to activation of bronchopulmonary C fibers may have also 
      played a role in the transient bronchoconstriction. These small exposure-related 
      decrements in pulmonary function were reversible.
FAU - Smith, C J
AU  - Smith CJ
AD  - Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco 
      Company, Winston-Salem, NC 27102-1487, USA.
FAU - Bombick, D W
AU  - Bombick DW
FAU - Ryan, B A
AU  - Ryan BA
FAU - Morton, M J
AU  - Morton MJ
FAU - Doolittle, D J
AU  - Doolittle DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Pathol
JT  - Toxicologic pathology
JID - 7905907
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Inhalation Exposure
MH  - Lung/*drug effects/*physiology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Tobacco Smoke Pollution/*adverse effects
EDAT- 2001/06/26 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/06/26 10:00
PHST- 2001/06/26 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/06/26 10:00 [entrez]
AID - 10.1080/019262301317052549 [doi]
PST - ppublish
SO  - Toxicol Pathol. 2001 Mar-Apr;29(2):260-4. doi: 10.1080/019262301317052549.