PMID- 11422090
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20220311
IS  - 0333-1024 (Print)
IS  - 0333-1024 (Linking)
VI  - 21
IP  - 2
DP  - 2001 Mar
TI  - Neuropeptide localization in the "migraine generator" region of the human 
      brainstem.
PG  - 96-101
AB  - Evidence from animals and humans suggests that brainstem nuclei such as the raphe 
      nuclei, the locus coeruleus (LC) and the periaqueductal grey matter (PAG), are 
      involved in the pathophysiology of migraine. In order to understand possible 
      neurotransmitters involved we have, by means of indirect immunocytochemistry, 
      analysed these regions for the occurrence and distribution of calcitonin 
      gene-related peptide (CGRP), substance P (SP), pituitary adenylate-cyclase 
      activating peptide (PACAP) and vasoactive intestinal polypeptide (VIP). 
      CGRP-immunoreactive (-ir) cell bodies, but no fibres, were found to occur in high 
      numbers, constituting 80% of all nerve cell bodies in the LC. A smaller number of 
      these nerve cell bodies (40%) in the LC proved to be PACAP-ir. The LC neurones 
      also stored the vesicular monoamine transporter (VMAT)- and the C-terminal 
      flanking peptide of neuropeptide Y (C-PON)-ir, illustrating their adrenergic 
      nature. Double immunostaining revealed that all VMAT-and C-PON-containing 
      neurones, in addition, stored CGRP. Immunoreactive cell bodies were not seen in 
      the nucleus raphe magnus (NRM) or PAG. Numerous SP-ir nerve fibres were observed 
      in the NRM, the LC and the PAG. Few PACAP-ir nerve fibres were detected in the 
      PAG and few VIP-ir nerve fibres were seen in the NRM and the PAG.
FAU - Tajti, J
AU  - Tajti J
AD  - Department of Neurology, Albert Szent-Gyorgyi University Medical School, Szeged, 
      Hungary.
FAU - Uddman, R
AU  - Uddman R
FAU - Edvinsson, L
AU  - Edvinsson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (ADCYAP1 protein, human)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Neuropeptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Pituitary Adenylate Cyclase-Activating Polypeptide)
RN  - 0 (neuropeptide Y C-terminal flanking peptide)
RN  - 33507-63-0 (Substance P)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Stem/*pathology
MH  - Calcitonin Gene-Related Peptide/*metabolism
MH  - Female
MH  - Humans
MH  - Locus Coeruleus/pathology
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*pathology
MH  - Neuropeptide Y/metabolism
MH  - Neuropeptides/*metabolism
MH  - Peptide Fragments/metabolism
MH  - Periaqueductal Gray/pathology
MH  - Pituitary Adenylate Cyclase-Activating Polypeptide
MH  - Raphe Nuclei/pathology
MH  - Substance P/metabolism
MH  - Vasoactive Intestinal Peptide/metabolism
EDAT- 2001/06/26 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/06/26 10:00
PHST- 2001/06/26 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/06/26 10:00 [entrez]
AID - cha140 [pii]
AID - 10.1046/j.1468-2982.2001.00140.x [doi]
PST - ppublish
SO  - Cephalalgia. 2001 Mar;21(2):96-101. doi: 10.1046/j.1468-2982.2001.00140.x.