PMID- 11423340
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 494
IP  - 1-2
DP  - 2001 Jul 25
TI  - Genotoxic effect of 2,4-dichlorophenoxy acetic acid and its metabolite 
      2,4-dichlorophenol in mouse.
PG  - 1-12
AB  - The cytogenetic effect of 2,4-dichlorophenoxy acetic acid (2,4-D) and its 
      metabolite 2,4-dichlorophenol (2,4-DCP) was studied in bone-marrow, germ cells 
      and sperm head abnormalities in the treated mice. Swiss mice were treated orally 
      by gavage with 2,4-D at 1.7, 3.3 and 33 mg kg(-1)BW (1/200, 1/100 and 1/10 of 
      LD(50)). 2,4-DCP was intraperitoneally (i.p.) injected at 36, 72 and 180 mg 
      kg(-1)BW (1/10, 1/5, 1/2 of LD(50)). A significant increase in the percentage of 
      chromosome aberrations in bone-marrow and spermatocyte cells was observed after 
      oral administration of 2,4-D at 3.3 mg kg(-1)BW for three and five consecutive 
      days. This percentage increased and reached 10.8+/-0.87 (P<0.01) in bone-marrow 
      and 9.8+/-0.45 (P<0.01) in spermatocyte cells after oral administration of 2,4-D 
      at 33 mg kg(-1)BW for 24 h. This percentage was, however, lower than that induced 
      in bone-marrow and spermatocyte cells by mitomycin C (positive control). 2,4-D 
      induced a dose-dependent increase in the percentage of sperm head abnormalities. 
      The genotoxic effect of 2,4-DCP is weaker than that of 2,4-D, as indicated by the 
      lower percentage of the induced chromosome aberrations (in bone-marrow and 
      spermatocyte cells) and sperm head abnormalities. Only the highest tested 
      concentration of 2,4-DCP (180 mg kg(-1)BW, 1/2 LD(50)) induced a significant 
      percentage of chromosome aberrations and sperm head abnormalities after i.p. 
      injection. The obtained results indicate that 2,4-D is genotoxic in mice in vivo 
      under the conditions tested. Hence, more care should be given to the application 
      of 2,4-D on edible crops since repeated uses may underlie a health hazard.
FAU - Amer, S M
AU  - Amer SM
AD  - Department of Genetics and Cytology, National Research Centre, Dokki, Cairo, 
      Egypt.
FAU - Aly, F A
AU  - Aly FA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Chlorophenols)
RN  - 0 (Herbicides)
RN  - 0 (Mutagens)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/*toxicity
MH  - Animals
MH  - Bone Marrow Cells/drug effects
MH  - Chlorophenols/*toxicity
MH  - Chromosome Aberrations
MH  - Dose-Response Relationship, Drug
MH  - Germ Cells/drug effects
MH  - Herbicides/*toxicity
MH  - Male
MH  - Mice
MH  - Mutagens/*toxicity
EDAT- 2001/06/26 10:00
MHDA- 2001/08/17 10:01
CRDT- 2001/06/26 10:00
PHST- 2001/06/26 10:00 [pubmed]
PHST- 2001/08/17 10:01 [medline]
PHST- 2001/06/26 10:00 [entrez]
AID - S1383571801001462 [pii]
AID - 10.1016/s1383-5718(01)00146-2 [doi]
PST - ppublish
SO  - Mutat Res. 2001 Jul 25;494(1-2):1-12. doi: 10.1016/s1383-5718(01)00146-2.