PMID- 11423723
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20171101
IS  - 1018-7782 (Print)
IS  - 1018-7782 (Linking)
VI  - 9
IP  - 4
DP  - 2001
TI  - Chemokine expression in the obstructed kidney.
PG  - 241-8
AB  - Chemokines are chemotactic cytokines that are important mediators of leukocyte 
      extravasation and chemotaxis. Herein, we provide evidence that after 1 day of 
      unilateral ureteral obstruction (UUO), the mouse obstructed kidney (OBK) 
      expresses MCP-1 (monocyte chemoattractant protein-1), RANTES (Regulated on 
      activation normal T-cell expressed and secreted) and IP-10 
      (interferon-gamma-induced protein-10). In addition, by day 7, MIP-2 (macrophage 
      inflammatory protein-2) expression is elevated in the obstructed kidneys compared 
      to the contralateral control kidneys (CLK). After 7 days of obstruction, RANTES 
      was the most abundant of the four chemokines detected in the OBK. In situ 
      hybridization results indicate that several cellular compartments contribute to 
      the expression of RANTES in the OBK. However, clearly cortical tubules within the 
      OBK contribute substantially to the elevated expression of RANTES. These data 
      support the contention that the cortical tubular epithelium plays a pivotal role 
      in the inflammation associated with experimental hydronephrosis.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Crisman, J M
AU  - Crisman JM
AD  - Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, 
      Hershey, Pa 17033-0850, USA. jmc35@psu.edu
FAU - Richards, L L
AU  - Richards LL
FAU - Valach, D P
AU  - Valach DP
FAU - Franzoni, D F
AU  - Franzoni DF
FAU - Diamond, J R
AU  - Diamond JR
LA  - eng
GR  - R01 DK53163/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Exp Nephrol
JT  - Experimental nephrology
JID - 9302239
RN  - 0 (CCL1 protein, human)
RN  - 0 (Ccr8 protein, mouse)
RN  - 0 (Chemokine CCL1)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cytokines)
RN  - 0 (Monokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR8)
SB  - IM
MH  - Animals
MH  - Chemokine CCL1
MH  - Chemokine CCL2/genetics
MH  - Chemokine CCL5/genetics
MH  - Chemokine CXCL10
MH  - Chemokine CXCL2
MH  - Chemokines/*genetics
MH  - Chemokines, CC
MH  - Chemokines, CXC/genetics
MH  - Cytokines/genetics
MH  - *Gene Expression
MH  - General Surgery
MH  - Hydronephrosis/etiology/metabolism
MH  - In Situ Hybridization
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Monokines/genetics
MH  - RNA, Messenger/analysis
MH  - Receptors, CCR8
MH  - Ureter
MH  - Ureteral Obstruction/etiology/*metabolism
EDAT- 2001/06/26 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/06/26 10:00
PHST- 2001/06/26 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/06/26 10:00 [entrez]
AID - 52618 [pii]
AID - 10.1159/000052618 [doi]
PST - ppublish
SO  - Exp Nephrol. 2001;9(4):241-8. doi: 10.1159/000052618.