PMID- 11426530
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 40
IP  - 5-6
DP  - 2001 Feb
TI  - Secondary chromosome changes in mantle cell lymphoma: cytogenetic and 
      fluorescence in situ hybridization studies.
PG  - 581-90
AB  - To better define the incidence and nature of secondary chromosome anomalies in 
      mantle cell lymphoma (MCL) carrying the t(11:14)/BCL1 rearrangement, cytogenetic 
      and fluorescence in situ hybridization studies (FISH) were performed in 42 
      patients (39 classical histology, 3 blastoid variant), using 6q21, 9p21/p16, 
      13q14, 17p13/p53 and chromosome-12-specific probes. Karyotypes from 89 cases 
      published in 5 recent series including patients diagnosed in a homogeneous 
      fashion were reviewed. In our series, FISH confirmed the interpretation of the 
      karyotype in all cases and disclosed cryptic chromosome deletions in a sizeable 
      fraction of cases. One patient (2.4% of total) was found with a cryptic 9p21 
      deletion by FISH. Two cases (4.8%) had a 6q21 deletion at CCA and at FISH; +12 
      was found in three cases by CCA plus nine by FISH (28.6%); 13q14 deletion was 
      found in six cases by CCA plus 16 by FISH (52.4%), 17p13 deletion in three cases 
      by CCA plus 8 by FISH (26.2%). In 131 patients (42 present series plus 89 in the 
      literature) secondary chromosome aberrations seen by conventional cytogenetic 
      analysis in more than 5 cases included deletions/translocations (del/t) 6q15-23 
      [15 cases]; -13 [14 cases]; del/t 1p21-31 [12 cases]; +3q [11 cases]; del/t 17p 
      [9 cases]; 8p translocations and del(Y) [8 cases each]; -20 [7 cases]; 13q14 
      deletion, del/t 11q22-23, del/t 9q, del(10)(q22q24), -20, -21, -22 and -X [6 
      cases each]. We arrived at the following conclusions: i) though no secondary 
      anomaly is specific for MCL, there is a distinct profile of recurrent chromosome 
      lesions in MCL with 1p21-31 deletions, 8p translocations, 11q22-23 anomalies 
      having a strong association with CD5+ B-cell lymphomas of low-to-intermediate 
      grade histology; ii) FISH enabled the detection of cryptic chromosome 12, 13q and 
      17p rearrangements in a sizeable fraction of cases; iii) 9p21/p16 deletions did 
      not occur at a high incidence in this series, possibly because of the low number 
      of cases with blastoid variant.
FAU - Bigoni, R
AU  - Bigoni R
AD  - Institute of Haematology, University of Ferrara, Italy.
FAU - Cuneo, A
AU  - Cuneo A
FAU - Milani, R
AU  - Milani R
FAU - Roberti, M G
AU  - Roberti MG
FAU - Bardi, A
AU  - Bardi A
FAU - Rigolin, G M
AU  - Rigolin GM
FAU - Cavazzini, F
AU  - Cavazzini F
FAU - Agostini, P
AU  - Agostini P
FAU - Castoldi, G
AU  - Castoldi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization
MH  - Karyotyping
MH  - Lymphoma, Mantle-Cell/*genetics
MH  - Time Factors
EDAT- 2001/06/28 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/06/28 10:00
PHST- 2001/06/28 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/06/28 10:00 [entrez]
AID - 10.3109/10428190109097656 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2001 Feb;40(5-6):581-90. doi: 10.3109/10428190109097656.