PMID- 11426601
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20190910
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 54
IP  - 4
DP  - 2001 Mar 15
TI  - Nanoindentation study of interfaces between calcium phosphate and bone in an 
      animal spinal fusion model.
PG  - 554-9
AB  - Intertransverse process spinal fusion is a common surgical procedure for the 
      treatment of spinal disorders. In the present study, a porous hydroxyapatite 
      (HA)/beta-tricalcium phosphate (beta-TCP) ceramic was tested as graft material 
      using a rabbit lumbar transverse process (L5-L6) fusion model. The porous ceramic 
      blocks were implanted onto the dorsal decorticated surface of the lumbar 
      transverse processes. The specimens were harvested at the seventh week after 
      implantation. Histomorphological observation revealed that the integration of 
      HA/beta-TCP with the host bone of the transverse process occurred by both 
      cancellous bone formation and cartilage formation. Scanning electron 
      microscopy-wavelength dispersive X-ray spectrometry examinations showed 
      significant differences in calcium, phosphorus, and sulfur contents in the newly 
      formed tissues and the porous HA/TCP implants. Nanoindentations were used to 
      evaluate the intrinsic mechanical properties of the implants and the newly formed 
      tissues. The Young's moduli of the newly formed cartilage, new cancellous bone, 
      and HA/TCP, were 0.66 +/- 0.02 GPa, 2.36 +/- 0.50 GPa, and 10.2 +/- 1.21 GPa, 
      respectively. Nanoindentation results revealed degradation of the porous ceramics 
      and incomplete calcification of the new cancellous bone at the seventh week after 
      implantation. Nanoindentation appeared to be a useful technique for assessing the 
      mechanical status of spinal fusion in animal models.
FAU - Guo, L
AU  - Guo L
AD  - Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 
      People's Republic of China. nic7500@scu.edu.cn
FAU - Guo, X
AU  - Guo X
FAU - Leng, Y
AU  - Leng Y
FAU - Cheng, J C
AU  - Cheng JC
FAU - Zhang, X
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
RN  - 91D9GV0Z28 (Durapatite)
RN  - K4C08XP666 (tricalcium phosphate)
SB  - IM
MH  - Animals
MH  - *Bone Substitutes
MH  - Calcium Phosphates/*chemistry/*metabolism
MH  - Cartilage, Articular/cytology/physiology
MH  - Durapatite/*chemistry
MH  - Lumbar Vertebrae/cytology/*physiology
MH  - Microscopy, Electron, Scanning
MH  - Models, Animal
MH  - Rabbits
MH  - Spectrometry, X-Ray Emission
MH  - *Spinal Fusion
EDAT- 2001/06/28 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/06/28 10:00
PHST- 2001/06/28 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/06/28 10:00 [entrez]
AID - 10.1002/1097-4636(20010315)54:4<554::aid-jbm120>3.0.co;2-9 [doi]
PST - ppublish
SO  - J Biomed Mater Res. 2001 Mar 15;54(4):554-9. doi: 
      10.1002/1097-4636(20010315)54:4<554::aid-jbm120>3.0.co;2-9.