PMID- 11428002
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20190826
IS  - 1523-7060 (Print)
IS  - 1523-7052 (Linking)
VI  - 3
IP  - 3
DP  - 2001 Feb 8
TI  - Pd-catalyzed asymmetric hydrogenation of alpha-fluorinated iminoesters in 
      fluorinated alcohol: a new and catalytic enantioselective synthesis of fluoro 
      alpha-amino acid derivatives.
PG  - 313-5
AB  - [figure: see text] Under hydrogen pressure, a catalytic amount of palladium(II) 
      trifluoroacetate and 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) promoted 
      asymmetric hydrogenation of alpha-fluorinated iminoesters to afford highly 
      enantioenriched beta-fluorinated alpha-amino esters. The yield and ee were much 
      improved by employing fluorinated alcohols such as 2,2,2-trifluoroethanol (up to 
      91% ee).
FAU - Abe, H
AU  - Abe H
AD  - Venture Business Laboratory, Graduate School of Natural Science and Technology, 
      and Department of Applied Chemistry, Faculty of Engineering, Okayama University, 
      Tsushimanaka, Okayama 700-8530, Japan.
FAU - Amii, H
AU  - Amii H
FAU - Uneyama, K
AU  - Uneyama K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Org Lett
JT  - Organic letters
JID - 100890393
RN  - 0 (Amino Acids)
RN  - 0 (Esters)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Imines)
RN  - 5TWQ1V240M (Palladium)
RN  - 75-89-8 (Trifluoroethanol)
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Amino Acids/*chemical synthesis
MH  - Esters/chemistry
MH  - Hydrocarbons, Fluorinated/*chemical synthesis
MH  - Hydrogen/chemistry
MH  - Imines/chemistry
MH  - Palladium
MH  - Stereoisomerism
MH  - Trifluoroethanol/chemistry
EDAT- 2001/06/29 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/06/29 10:00
PHST- 2001/06/29 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/29 10:00 [entrez]
AID - 10.1021/ol0002471 [doi]
PST - ppublish
SO  - Org Lett. 2001 Feb 8;3(3):313-5. doi: 10.1021/ol0002471.