PMID- 11428907
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20161124
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 44
IP  - 1
DP  - 2001 Jul
TI  - MDMA ("ecstasy") exhibits an anxiogenic-like activity in social encounters 
      between male mice.
PG  - 27-31
AB  - Recent studies have suggested that 3,4-methylenedioxymethamphetamine (MDMA; 
      "ecstasy"), a synthetic amphetamine derivative, might exhibit an anxiogenic-like 
      activity in rodents. In this work, we examined the effects of MDMA (1, 8 and 15 
      mg kg(-1), i.p.) on social encounters between male mice using an 
      ethopharmacological approach. Likewise, we compared the behavioural profile of 
      MDMA with that induced by FG 7142 (15 mg kg(-1), i.p.), an anxiogenic 
      benzodiazepine receptor ligand. Individually housed mice were exposed to anosmic 
      standard opponents 30 min after drug administration, and the encounters were 
      videotaped and evaluated using an ethologically based analysis. MDMA (8 and 15 mg 
      kg(-1)) produced a behavioural pattern characterized by a marked decrease of 
      aggression (threat and attack) as well as social investigation, body care and 
      digging behaviours, without affecting immobility. Moreover, avoidance/flee and 
      defence/submission behaviours were significantly increased by the drug. A very 
      similar behavioural profile was observed in FG 7142-treated animals. Overall, 
      these findings might indicate that MDMA has anxiogenic-like properties in male 
      mice.
CI  - Copyright 2001 Academic Press.
FAU - Maldonado, E
AU  - Maldonado E
AD  - Department of Psychobiology, Faculty of Psychology, Campus de Teatinos, 
      University of Malaga, 29071 Malaga, Spain.
FAU - Navarro, J F
AU  - Navarro JF
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Carbolines)
RN  - 0 (GABA Antagonists)
RN  - 60PO70N1BP (FG 7142)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Carbolines/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Psychomotor Performance/*drug effects
MH  - *Social Behavior
EDAT- 2001/06/29 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/06/29 10:00
PHST- 2001/06/29 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/06/29 10:00 [entrez]
AID - S1043-6618(01)90824-2 [pii]
AID - 10.1006/phrs.2001.0824 [doi]
PST - ppublish
SO  - Pharmacol Res. 2001 Jul;44(1):27-31. doi: 10.1006/phrs.2001.0824.