PMID- 11429541
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20220228
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 2
IP  - 7
DP  - 2001 Jul
TI  - Dendritic cell lineage, plasticity and cross-regulation.
PG  - 585-9
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that have an 
      extraordinary capacity to stimulate naive T cells and initiate primary immune 
      responses. Here we review progress in understanding the additional functions of 
      DCs in regulating the types of T cell-mediated immune responses and innate 
      immunity to microbes. In addition, evidence for the existence of myeloid and 
      lymphoid DC lineages and their different functions are summarized. We propose 
      that the diverse functions of DCs in immune regulation are dictated by the 
      instructions they received during innate immune responses to different pathogens 
      and from their evolutionary lineage heritage.
FAU - Liu, Y J
AU  - Liu YJ
AD  - DNAX Research Institute, 901 California Ave., Palo Alto, CA 94304, USA. 
      yliu@dnax.org
FAU - Kanzler, H
AU  - Kanzler H
FAU - Soumelis, V
AU  - Soumelis V
FAU - Gilliet, M
AU  - Gilliet M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Interferon Type I)
RN  - 0 (invariant chain)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation, B-Lymphocyte
MH  - Cell Lineage
MH  - Cross Reactions
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*immunology/physiology
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Interferon Type I/biosynthesis
MH  - Interferon-gamma/immunology
MH  - Lymphoid Tissue/cytology/immunology
MH  - Th1 Cells/cytology/*immunology
MH  - Th2 Cells/cytology/*immunology
RF  - 87
EDAT- 2001/06/29 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/06/29 10:00
PHST- 2001/06/29 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/06/29 10:00 [entrez]
AID - 89726 [pii]
AID - 10.1038/89726 [doi]
PST - ppublish
SO  - Nat Immunol. 2001 Jul;2(7):585-9. doi: 10.1038/89726.