PMID- 11430927
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 422
IP  - 1-3
DP  - 2001 Jun 22
TI  - Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of 
      rat right ventricle and small mesenteric artery.
PG  - 169-74
AB  - We have compared the effects of methylenedioxymethamphetamine (MDMA) and cocaine 
      on contractions to noradrenaline in 1 Hz paced rat right ventricular strips, and 
      in rat small mesenteric artery and aorta. Noradrenaline increased the force of 
      contraction of 1 Hz paced ventricular strips with a pD(2) (-log EC(50)) of 
      5.64+/-0.07. Both cocaine (10 microM) and MDMA (10 microM) significantly 
      increased the potency of noradrenaline to 6.31+/-0.11 and 6.42+/-0.13, 
      respectively. However, in the presence of cocaine (10 microM) which increased the 
      potency of noradrenaline to 6.78+/-0.15, MDMA (10 microM) no longer increased the 
      potency of noradrenaline (pD(2) of 6.78+/-0.32). Likewise, following chemical 
      sympathectomy, MDMA failed to increase the potency of noradrenaline. The potency 
      of the agonist isoprenaline, which is not a substrate for the noradrenaline 
      transporter, was not increased by either cocaine or MDMA. In rat small mesenteric 
      artery, but not aorta, MDMA and cocaine significantly increased the potency of 
      noradrenaline, but in the presence of cocaine, MDMA had no further effect. Hence, 
      MDMA shares with cocaine an ability to potentiate the actions of noradrenaline, 
      an action in the case of MDMA which may involve competitive blockade of the 
      noradrenaline transporter, rather than simply displacement of noradrenaline. 
      Since cocaine is linked to an increased incidence of myocardial infarction, these 
      results may have implications in terms of cardiac morbidity of MDMA.
FAU - Al-Sahli, W
AU  - Al-Sahli W
AD  - Department of Physiology, Royal College of Surgeons in Ireland, 123 St. Stephen's 
      Green, Dublin 2, Ireland.
FAU - Ahmad, H
AU  - Ahmad H
FAU - Kheradmand, F
AU  - Kheradmand F
FAU - Connolly, C
AU  - Connolly C
FAU - Docherty, J R
AU  - Docherty JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Vasoconstrictor Agents)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/drug effects/physiology
MH  - Cocaine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Heart Ventricles/*drug effects/innervation
MH  - In Vitro Techniques
MH  - Male
MH  - Mesenteric Arteries/*drug effects/physiology
MH  - Myocardial Contraction/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Norepinephrine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sympathectomy
MH  - Vasoconstriction/*drug effects
MH  - Vasoconstrictor Agents/pharmacology
MH  - Ventricular Function
EDAT- 2001/06/30 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/06/30 10:00
PHST- 2001/06/30 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/06/30 10:00 [entrez]
AID - S0014299901010706 [pii]
AID - 10.1016/s0014-2999(01)01070-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 Jun 22;422(1-3):169-74. doi: 10.1016/s0014-2999(01)01070-6.