PMID- 11431000
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 117
IP  - 1-2
DP  - 2001 Jul 2
TI  - Narcolepsy and the HLA region.
PG  - 9-20
AB  - Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, 
      suggesting a possible autoimmune mechanism. Early investigations failed to 
      demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker 
      for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now 
      being re-evaluated under the light of recent results. Like many other autoimmune 
      disorders, narcolepsy usually starts during adolescence, is human leukocyte 
      antigen (HLA)-associated, multigenic and environmentally influenced. Furthermore, 
      HLA-association studies indicated a primary HLA-DQ effect with complex HLA class 
      II allele interactions and a partial contribution of HLA to overall genetic 
      susceptibility. Finally, recent result suggests that human narcolepsy is 
      associated with the destruction of a small number of hypothalamic neurons 
      containing the peptide hypocretins (orexins). This data is consistent with an 
      immune destruction of hypocretin-containing cells as the most common etiology for 
      human narcolepsy.
FAU - Lin, L
AU  - Lin L
AD  - Department of Psychiatry and Behavioral Sciences, Stanford Center for Narcolepsy, 
      Stanford University Medical Center, 1201 Welch Road, P-114, Palo Alto, CA 
      94305-5485, USA.
FAU - Hungs, M
AU  - Hungs M
FAU - Mignot, E
AU  - Mignot E
LA  - eng
GR  - HL59601/HL/NHLBI NIH HHS/United States
GR  - NS23724/NS/NINDS NIH HHS/United States
GR  - NS33797/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Carrier Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ1 antigen)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Autoimmunity
MH  - Carrier Proteins/physiology
MH  - Dogs
MH  - HLA-DQ Antigens/chemistry/*genetics/physiology
MH  - HLA-DR2 Antigen/chemistry/*genetics/physiology
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Microsatellite Repeats
MH  - Molecular Sequence Data
MH  - Narcolepsy/*immunology/pathology/therapy
MH  - Neuropeptides/physiology
MH  - Orexins
MH  - Structure-Activity Relationship
RF  - 96
EDAT- 2001/06/30 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/06/30 10:00
PHST- 2001/06/30 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/06/30 10:00 [entrez]
AID - S0165572801003332 [pii]
AID - 10.1016/s0165-5728(01)00333-2 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2001 Jul 2;117(1-2):9-20. doi: 10.1016/s0165-5728(01)00333-2.