PMID- 11433522
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20211203
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 31
IP  - 4
DP  - 2001 Aug
TI  - Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell 
      lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract.
PG  - 316-25
AB  - Extranodal B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type may 
      represent a model of lymphoma progression, because a small cell component 
      frequently occurs in the large cell variants. We studied 52 extranodal B-cell 
      lymphomas: 18 extranodal marginal zone B-cell lymphomas of MALT type (MZBL,MT), 7 
      MZBL,MT of the gastro-intestinal tract with a diffuse large B-cell component 
      (giMZBLplusLBCL), and 27 diffuse large B-cell lymphomas of the gastro-intestinal 
      tract without small cell component (giLBCL). Analytical techniques were 
      comparative genomic hybridization (CGH) and fluorescence in situ hybridization 
      (FISH). The translocation t(11;18) was found as the sole aberration in two 
      MZBL,MT only. In contrast to this, t(11;18)-negative MZBL,MT were characterized 
      by frequent gains on chromosome 3 and DNA amplifications on 2p13-p15. 
      Furthermore, we found a clonal lymphoma progression from the small to the large 
      cell component with accumulation of gains and losses of chromosomal material in 
      the large cell component in giMZBLplusLBCL. Aberrations overlapping with MZBL,MT 
      and giMZBLplusLBCL included losses on chromosome 13, amplifications of the REL 
      proto-oncogene, or gains on chromosome 12. In addition, the large cell component 
      revealed gains on 8q24, including amplifications of the MYC proto-oncogene, and 
      losses on 2q. The giLBCL had frequent gains on chromosomes 12 and 9, as well as 
      on 11q, and losses on 6q. We conclude that, based on the distinctive and partly 
      overlapping patterns of genetic aberrations, MALT lymphomas can be divided into 
      different genetic subgroups.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Barth, T F
AU  - Barth TF
AD  - Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89091 Ulm, 
      Germany. thomas.barth@medizin.uni-ulm.de
FAU - Bentz, M
AU  - Bentz M
FAU - Leithauser, F
AU  - Leithauser F
FAU - Stilgenbauer, S
AU  - Stilgenbauer S
FAU - Siebert, R
AU  - Siebert R
FAU - Schlotter, M
AU  - Schlotter M
FAU - Schlenk, R F
AU  - Schlenk RF
FAU - Dohner, H
AU  - Dohner H
FAU - Moller, P
AU  - Moller P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Chromosome Aberrations/genetics
MH  - Chromosome Deletion
MH  - Clone Cells
MH  - *Cytogenetic Analysis
MH  - Gastrointestinal Neoplasms/*genetics
MH  - Gene Amplification/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Nucleic Acid Hybridization
MH  - Proto-Oncogene Mas
MH  - Translocation, Genetic/genetics
EDAT- 2001/07/04 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/07/04 10:00
PHST- 2001/07/04 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/07/04 10:00 [entrez]
AID - 10.1002/gcc.1150 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2001 Aug;31(4):316-25. doi: 10.1002/gcc.1150.