PMID- 11434474
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20220316
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 20
IP  - 3
DP  - 2001
TI  - Undifferentiated spondyloarthropathies: a 2-year follow-up study.
PG  - 201-6
AB  - The aim of the study was to analyse the 2-year follow-up of a series of patients 
      with the diagnosis of undifferentiated spondyloarthropathy (uSpA). A prospective 
      study was carried out analysing 68 patients with symptomatic uSpA who fulfilled 
      the European Spondylarthropathy Study Group (ESSG) criteria for seronegative 
      spondyloarthropathies (SpA) and were aged between 18 and 50 years. Inclusion 
      criteria included inflammatory low back pain (ILBP) (without radiographic 
      sacroiliitis), asymmetric oligoarthritis (predominantly affecting large joints in 
      the lower limbs) and heel enthesopathies (Achilles tendinitis and/or plantar 
      fasciitis). Imaging methods included pelvic radiography (at study entry and after 
      2 years) and calcaneal radiography (at study entry). There was a predominance of 
      male gender (78%), caucasoid race (72%) and positive HLA-B27 (54%), with a mean 
      age of 31 years and mean disease duration of 5 years. The first disease 
      manifestations were ILBP (49%), asymmetric oligoarthritis (35%) and heel 
      enthesopathies (16%). A positive family history of a definite SpA was mentioned 
      by 9% of the patients. Seventeen patients (25%) scored 5 points in the Amor set 
      of SpA criteria; logistic regression analysis showed that HLA-B27, heel 
      enthesopathy and asymmetric oligoarthritis were significantly associated with 
      Amor criteria > or = 6, whereas ILBP was associated with Amor criteria <6. Male 
      sex was associated with heel enthesopathies (p = 0.041) and ankle involvement (p 
      = 0.015). Caucasoid race was associated with ILBP (p=0.015) and buttock pain (p = 
      0.047). Positive HLA-B27 was associated with wrist involvement (p=0.019) and Amor 
      criteria > or = 6 (p=0.001). After a 2-year follow-up the following outcomes were 
      observed: uSpA 75%; disease remission 13%; ankylosing spondylitis 10%; psoriatic 
      arthritis 2%. Logistic regression analysis showed that buttock pain and positive 
      HLA-B27 (trend) were statistically associated with progression to a definite SpA. 
      In conclusion, uSpA can represent a provisional diagnosis in the group of SpA and 
      a systematic follow-up is necessary in order to better establish the different 
      patterns of the disease.
FAU - Sampaio-Barros, P D
AU  - Sampaio-Barros PD
AD  - Depto. de Clinica Medica, State University of Campinas Faculty of Medical 
      Sciences, SP, Brazil. psbarros@bestway.com.br
FAU - Bertolo, M B
AU  - Bertolo MB
FAU - Kraemer, M H
AU  - Kraemer MH
FAU - Marques-Neto, J F
AU  - Marques-Neto JF
FAU - Samara, A M
AU  - Samara AM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
SB  - IM
MH  - Adult
MH  - Arthritis/classification/*diagnosis/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Spinal Diseases/classification/*diagnosis/physiopathology
EDAT- 2001/07/04 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/07/04 10:00
PHST- 2001/07/04 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/07/04 10:00 [entrez]
AID - 10.1007/s100670170066 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2001;20(3):201-6. doi: 10.1007/s100670170066.